Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2826745..2827396 Replicon chromosome
Accession NZ_CP051875
Organism Acinetobacter baumannii strain Ab-B004d-c

Toxin (Protein)


Gene name hicA Uniprot ID A0A858S855
Locus tag HIN86_RS13605 Protein ID WP_057048946.1
Coordinates 2827214..2827396 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N8SBQ4
Locus tag HIN86_RS13600 Protein ID WP_004700312.1
Coordinates 2826745..2827149 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIN86_RS13580 2822252..2825212 - 2961 Protein_2659 tape measure protein -
HIN86_RS13585 2825271..2825672 - 402 WP_000758222.1 hypothetical protein -
HIN86_RS13590 2825684..2826220 - 537 WP_057048948.1 hypothetical protein -
HIN86_RS13595 2826276..2826638 - 363 WP_057048947.1 hypothetical protein -
HIN86_RS13600 2826745..2827149 - 405 WP_004700312.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HIN86_RS13605 2827214..2827396 - 183 WP_057048946.1 type II toxin-antitoxin system HicA family toxin Toxin
HIN86_RS13610 2827746..2828258 - 513 WP_057048945.1 hypothetical protein -
HIN86_RS13615 2828308..2829243 - 936 WP_057048944.1 hypothetical protein -
HIN86_RS13620 2829348..2829560 - 213 WP_004700304.1 hypothetical protein -
HIN86_RS13625 2829562..2830005 - 444 WP_153886541.1 hypothetical protein -
HIN86_RS13630 2829962..2830330 - 369 WP_001983390.1 hypothetical protein -
HIN86_RS13635 2830296..2830712 - 417 WP_057048942.1 hypothetical protein -
HIN86_RS13640 2830772..2831608 - 837 WP_057048941.1 hypothetical protein -
HIN86_RS13645 2831657..2832028 - 372 WP_057048940.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2803977..2856189 52212


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6664.81 Da        Isoelectric Point: 10.5523

>T155396 WP_057048946.1 NZ_CP051875:c2827396-2827214 [Acinetobacter baumannii]
VKSLDLIKLIEADGWYEVRVTGSHHHFKHPNKKGLVTIPHPKKDLPSGTVKSILKQAGLT

Download         Length: 183 bp

>T155396 NZ_CP068800:c4059952-4059032 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCCGGCAGGTCAAACTGTTGATGGCCGCTCTGCCGTATGTGGCGAAGGAGTCCTGTTT
CGCGTTGAAAGGCGGCACCGCAATCAATTTGTTTGTGCAGGATTTTCCCCGTCTGTCGGTGGATATTGATCTGGCGTACA
AGAGCTTTGCGGATCGCGATACTGATTTGGCGGCTATCAACGACGCTTTGAAGAGGATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATCTGCGCTGCGCTTGATCGTCAGCAC
CCGCGCGATCTGTTTGATGTGCTGAATATGCTGGAGAAACCGGGACTGATGCGGGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGCCCCATCGCCGAGTTGCTGGCTCCAAACTGGGATACAGAGCGGATCGCCACGTTGTACGCGC
AGGAATTTTCAGGGATGACGCAACAGGAAACGTCGCTGGAATCGCTTCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATCTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGGTGCTTAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTTCTGGCGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14761.80 Da        Isoelectric Point: 4.4367

>AT155396 WP_004700312.1 NZ_CP051875:c2827149-2826745 [Acinetobacter baumannii]
MLYPIAIERGIDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT155396 NZ_CP068800:c4060721-4059939 [Escherichia coli]
TTGCCAAACTATCTAAACTGGCTGATGCAGCACACGCTACCCGGCCAGGTGCTGCTCCAGTCATGGCTTACCCGCAACGG
CATAGATCGTAAGCTCTCTTATCTCTATGTGAAGAATGGCTGGCTCAGGCGGATCGCTCACGGCGTATACTGCCGGACGG
GTCGTGAACCGGATTGGGTGGATGCGGTTTACTGCCTGCAATCGCAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGTCATGCGCACTATACCGAACAGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTCAA
ACTGCCGGGATGGTTTTCTGCCTTTGAACAATCCGCAACGTTTGTCACGCTGTATACGTCAGGCCTTACCGCTGATGTAA
CGCCATTTACTACGGAACTGAAAATTGGCGACCGCCAGTTAGCAGGCAGTGTTCCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTAATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGTTGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGCCATTCGGTTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATATTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCCGGCGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCACGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A858S855

Antitoxin

Source ID Structure
AlphaFold DB N8SBQ4

References