Detailed information of TA system TA155395

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1985952..1987588
• Replicon: chromosome
• Accession: NZ_CP051875
• Organism: Acinetobacter baumannii strain Ab-B004d-c

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A858S2C4
• Locus tag: HIN86_RS09555
• Protein ID: WP_031379782.1
• Coordinates: 1985952..1987283 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HIN86_RS09560
• Protein ID: WP_001101310.1
• Coordinates: 1987280..1987588 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HIN86_RS09530	1981033..1982271	+	1239	WP_111818114.1	TolC family protein	-
HIN86_RS09535	1982264..1983427	+	1164	WP_032000316.1	hypothetical protein	-
HIN86_RS09540	1983554..1984525	+	972	WP_111818113.1	5'/3'-nucleotidase SurE	-
HIN86_RS09545	1984537..1985181	+	645	WP_032000318.1	hypothetical protein	-
HIN86_RS09550	1985216..1985656	-	441	WP_057048971.1	HD domain-containing protein	-
HIN86_RS09555	1985952..1987283	+	1332	WP_031379782.1	type II toxin-antitoxin system HipA family toxin	Toxin
HIN86_RS09560	1987280..1987588	+	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
HIN86_RS09565	1988313..1988879	+	567	WP_032000319.1	TetR/AcrR family transcriptional regulator	-
HIN86_RS09570	1988952..1989578	+	627	WP_032000320.1	hypothetical protein	-
HIN86_RS09575	1989641..1990057	+	417	WP_032000322.1	hypothetical protein	-
HIN86_RS09580	1990151..1990669	+	519	WP_032000323.1	GNAT family N-acetyltransferase	-
HIN86_RS09585	1990875..1991657	+	783	WP_032000324.1	HNH endonuclease	-
HIN86_RS09590	1991741..1992577	-	837	WP_032000325.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51202.34 Da
• Isoelectric Point: 4.9820

>T155395 WP_031379782.1 NZ_CP051875:1985952-1987283 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELNYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T155395 NZ_CP068800:3854763-3854981 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT155395 WP_001101310.1 NZ_CP051875:1987280-1987588 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT155395 NZ_CP068800:3854363-3854737 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A858S2C4