Detailed information of TA system TA155394

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 463096..463737
• Replicon: chromosome
• Accession: NZ_CP051875
• Organism: Acinetobacter baumannii strain Ab-B004d-c

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A858S2K0
• Locus tag: HIN86_RS02220
• Protein ID: WP_031999513.1
• Coordinates: 463348..463737 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HIN86_RS02215
• Protein ID: WP_011860336.1
• Coordinates: 463096..463341 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HIN86_RS02195	458600..459607	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
HIN86_RS02200	459626..460003	+	378	WP_001216380.1	50S ribosomal protein L17	-
HIN86_RS02205	460185..461675	+	1491	WP_000415132.1	NAD(P)/FAD-dependent oxidoreductase	-
HIN86_RS02210	461724..462896	-	1173	WP_017725189.1	acyl-CoA dehydrogenase family protein	-
HIN86_RS02215	463096..463341	+	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
HIN86_RS02220	463348..463737	+	390	WP_031999513.1	membrane protein	Toxin
HIN86_RS02225	464507..465592	+	1086	WP_031999514.1	hypothetical protein	-
HIN86_RS02230	465670..466236	+	567	WP_000651536.1	rhombosortase	-
HIN86_RS02235	466424..468619	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15598.85 Da
• Isoelectric Point: 10.3889

>T155394 WP_031999513.1 NZ_CP051875:463348-463737 [Acinetobacter baumannii]
MVNHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYQSQNTV
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T155394 NZ_CP068800:3449177-3449563 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT155394 WP_011860336.1 NZ_CP051875:463096-463341 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT155394 NZ_CP068800:3449553-3449882 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A858S2K0