Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2535160..2535811 Replicon chromosome
Accession NZ_CP051869
Organism Acinetobacter baumannii strain Ab-D10a-a

Toxin (Protein)


Gene name hicA Uniprot ID A0A858S855
Locus tag HIN87_RS12385 Protein ID WP_057048946.1
Coordinates 2535160..2535342 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N8SBQ4
Locus tag HIN87_RS12390 Protein ID WP_004700312.1
Coordinates 2535407..2535811 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIN87_RS12345 2530528..2530899 + 372 WP_057048940.1 hypothetical protein -
HIN87_RS12350 2530984..2531784 + 801 WP_169040857.1 hypothetical protein -
HIN87_RS12355 2531844..2532260 + 417 WP_057048942.1 hypothetical protein -
HIN87_RS12360 2532226..2532594 + 369 WP_001983390.1 hypothetical protein -
HIN87_RS12365 2532551..2532994 + 444 WP_153886541.1 hypothetical protein -
HIN87_RS12370 2532996..2533208 + 213 WP_004700304.1 hypothetical protein -
HIN87_RS12375 2533313..2534248 + 936 WP_057048944.1 hypothetical protein -
HIN87_RS12380 2534298..2534810 + 513 WP_057048945.1 hypothetical protein -
HIN87_RS12385 2535160..2535342 + 183 WP_057048946.1 type II toxin-antitoxin system HicA family toxin Toxin
HIN87_RS12390 2535407..2535811 + 405 WP_004700312.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HIN87_RS12395 2535918..2536280 + 363 WP_057048947.1 hypothetical protein -
HIN87_RS12400 2536336..2536872 + 537 WP_057048948.1 hypothetical protein -
HIN87_RS12405 2536884..2537285 + 402 WP_000758222.1 hypothetical protein -
HIN87_RS12410 2537344..2540304 + 2961 Protein_2397 tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2510270..2558579 48309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6664.81 Da        Isoelectric Point: 10.5523

>T155391 WP_057048946.1 NZ_CP051869:2535160-2535342 [Acinetobacter baumannii]
VKSLDLIKLIEADGWYEVRVTGSHHHFKHPNKKGLVTIPHPKKDLPSGTVKSILKQAGLT

Download         Length: 183 bp

>T155391 NZ_CP068800:3056423-3056530 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14761.80 Da        Isoelectric Point: 4.4367

>AT155391 WP_004700312.1 NZ_CP051869:2535407-2535811 [Acinetobacter baumannii]
MLYPIAIERGIDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT155391 NZ_CP068800:c3056376-3056310 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A858S855

Antitoxin

Source ID Structure
AlphaFold DB N8SBQ4

References