Detailed information of TA system TA155386

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 457058..457699
• Replicon: chromosome
• Accession: NZ_CP051866
• Organism: Acinetobacter baumannii strain Ab-C63

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A7Z1WP95
• Locus tag: HIN88_RS02210
• Protein ID: WP_002061280.1
• Coordinates: 457310..457699 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HIN88_RS02205
• Protein ID: WP_011860336.1
• Coordinates: 457058..457303 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HIN88_RS02185	452562..453569	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
HIN88_RS02190	453588..453965	+	378	WP_001216380.1	50S ribosomal protein L17	-
HIN88_RS02195	454147..455637	+	1491	WP_032046399.1	NAD(P)/FAD-dependent oxidoreductase	-
HIN88_RS02200	455686..456858	-	1173	WP_001190546.1	acyl-CoA dehydrogenase family protein	-
HIN88_RS02205	457058..457303	+	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
HIN88_RS02210	457310..457699	+	390	WP_002061280.1	hypothetical protein	Toxin
HIN88_RS02215	458469..459554	+	1086	WP_000049106.1	hypothetical protein	-
HIN88_RS02220	459632..460198	+	567	WP_064193062.1	rhombosortase	-
HIN88_RS02225	460386..462581	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15635.96 Da
• Isoelectric Point: 10.4623

>T155386 WP_002061280.1 NZ_CP051866:457310-457699 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T155386 NZ_CP068800:1191553-1191888 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT155386 WP_011860336.1 NZ_CP051866:457058-457303 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT155386 NZ_CP068800:1191305-1191553 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: A0A7Z1WP95