Detailed information of TA system TA155378

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1914589..1916225
• Replicon: chromosome
• Accession: NZ_CP051862
• Organism: Acinetobacter baumannii strain Ab-C102

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A158LVC8
• Locus tag: HIN89_RS09105
• Protein ID: WP_002163265.1
• Coordinates: 1914894..1916225 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HIN89_RS09100
• Protein ID: WP_001101310.1
• Coordinates: 1914589..1914897 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HIN89_RS09065	1909598..1909893	-	296	Protein_1764	hypothetical protein	-
HIN89_RS09070	1910110..1910949	+	840	WP_004834846.1	PAAR domain-containing protein	-
HIN89_RS09075	1910946..1911647	+	702	WP_004834844.1	hypothetical protein	-
HIN89_RS09080	1911857..1912789	-	933	WP_049590967.1	IS5-like element ISAba13 family transposase	-
HIN89_RS09085	1912831..1913004	+	174	WP_002126882.1	hypothetical protein	-
HIN89_RS09090	1913057..1913260	-	204	WP_025467286.1	hypothetical protein	-
HIN89_RS09095	1913305..1913865	-	561	WP_002126886.1	TetR/AcrR family transcriptional regulator	-
HIN89_RS09100	1914589..1914897	-	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
HIN89_RS09105	1914894..1916225	-	1332	WP_002163265.1	type II toxin-antitoxin system HipA family toxin	Toxin
HIN89_RS09110	1916521..1916961	+	441	WP_002126884.1	HD domain-containing protein	-
HIN89_RS09115	1916997..1917641	-	645	WP_002163276.1	hypothetical protein	-
HIN89_RS09120	1917673..1918620	-	948	WP_002163270.1	5'/3'-nucleotidase SurE	-
HIN89_RS09125	1918750..1919913	-	1164	WP_002163272.1	hypothetical protein	-
HIN89_RS09130	1919906..1921144	-	1239	WP_169041036.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1911857..1912789	932

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51233.35 Da
• Isoelectric Point: 4.9177

>T155378 WP_002163265.1 NZ_CP051862:c1916225-1914894 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SSGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T155378 NZ_CP068800:216697-216804 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT155378 WP_001101310.1 NZ_CP051862:c1914897-1914589 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT155378 NZ_CP068800:c216639-216585 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A158LVC8