Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1866594..1867073 Replicon chromosome
Accession NZ_CP051862
Organism Acinetobacter baumannii strain Ab-C102

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HIN89_RS08830 Protein ID WP_079283165.1
Coordinates 1866876..1867073 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HIN89_RS08825 Protein ID WP_000985610.1
Coordinates 1866594..1866875 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIN89_RS08810 1862802..1864013 + 1212 WP_086231556.1 alpha/beta hydrolase -
HIN89_RS08815 1864106..1865194 - 1089 Protein_1715 LLM class flavin-dependent oxidoreductase -
HIN89_RS08820 1865434..1866366 - 933 WP_002056344.1 IS5-like element ISAba13 family transposase -
HIN89_RS08825 1866594..1866875 - 282 WP_000985610.1 putative addiction module antidote protein Antitoxin
HIN89_RS08830 1866876..1867073 - 198 WP_079283165.1 addiction module killer protein Toxin
HIN89_RS08835 1867079..1868312 - 1234 Protein_1719 IS3 family transposase -
HIN89_RS08840 1868422..1868646 + 225 Protein_1720 IS1 family transposase -
HIN89_RS08850 1869080..1869355 + 276 WP_001133624.1 metal/formaldehyde-sensitive transcriptional repressor -
HIN89_RS08855 1869377..1870489 + 1113 WP_038343718.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
HIN89_RS08860 1870720..1871550 + 831 WP_004740248.1 S-formylglutathione hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1865434..1867981 2547


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(6-60)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7391.56 Da        Isoelectric Point: 9.5998

>T155376 WP_079283165.1 NZ_CP051862:c1867073-1866876 [Acinetobacter baumannii]
IKKSPTNPVRFSVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKSTQSKDIKLALQLAQDLEEEL

Download         Length: 198 bp

>T155376 NZ_CP068799:c5013929-5013618 [Escherichia coli]
ATCCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10109.67 Da        Isoelectric Point: 8.0018

>AT155376 WP_000985610.1 NZ_CP051862:c1866875-1866594 [Acinetobacter baumannii]
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Download         Length: 282 bp

>AT155376 NZ_CP068799:c5013617-5013327 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References