Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4243554..4244352 | Replicon | chromosome |
| Accession | NZ_CP051849 | ||
| Organism | Escherichia coli strain SCU-101 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | HHJ20_RS20685 | Protein ID | WP_000854737.1 |
| Coordinates | 4243975..4244352 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0P7R0L9 |
| Locus tag | HHJ20_RS20680 | Protein ID | WP_001285482.1 |
| Coordinates | 4243554..4243928 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HHJ20_RS20635 (4238580) | 4238580..4239035 | - | 456 | WP_169711463.1 | phage tail protein | - |
| HHJ20_RS20640 (4239064) | 4239064..4239573 | - | 510 | Protein_4079 | phage tail protein | - |
| HHJ20_RS20645 (4239639) | 4239639..4240211 | + | 573 | WP_000904922.1 | recombinase family protein | - |
| HHJ20_RS20650 (4240432) | 4240432..4241253 | + | 822 | WP_021567056.1 | DUF932 domain-containing protein | - |
| HHJ20_RS20655 (4241253) | 4241253..4241498 | + | 246 | WP_001164966.1 | hypothetical protein | - |
| HHJ20_RS20660 (4241592) | 4241592..4242065 | + | 474 | WP_001313575.1 | antirestriction protein | - |
| HHJ20_RS20665 (4242081) | 4242081..4242557 | + | 477 | WP_001186170.1 | RadC family protein | - |
| HHJ20_RS20670 (4242620) | 4242620..4242841 | + | 222 | WP_000692315.1 | DUF987 domain-containing protein | - |
| HHJ20_RS20675 (4242860) | 4242860..4243504 | + | 645 | WP_000086759.1 | hypothetical protein | - |
| HHJ20_RS20680 (4243554) | 4243554..4243928 | + | 375 | WP_001285482.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HHJ20_RS20685 (4243975) | 4243975..4244352 | + | 378 | WP_000854737.1 | TA system toxin CbtA family protein | Toxin |
| HHJ20_RS20690 (4244349) | 4244349..4244841 | + | 493 | Protein_4089 | DUF5983 family protein | - |
| HHJ20_RS20695 (4244920) | 4244920..4245908 | - | 989 | Protein_4090 | IS630 family transposase | - |
| HHJ20_RS20700 (4246056) | 4246056..4246244 | - | 189 | Protein_4091 | IS66 family transposase | - |
| HHJ20_RS20705 (4246305) | 4246305..4247438 | + | 1134 | WP_000555410.1 | IS110-like element ISEc45 family transposase | - |
| HHJ20_RS20710 (4247825) | 4247825..4248958 | + | 1134 | WP_000555410.1 | IS110-like element ISEc45 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | IlpA | 4197493..4272443 | 74950 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14240.26 Da Isoelectric Point: 7.8051
>T155347 WP_000854737.1 NZ_CP051849:4243975-4244352 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR
Download Length: 378 bp
>T155347 NZ_CP068798:c3283879-3283703 [Klebsiella pneumoniae]
GTGAAGCAAAGCGAGTTGAGGCGTTGGCTTGCAGCTCAAGGGGCAGAATTTAAAGATGGTACTAACCACTTGAAAATCTA
TCTCAACGGCAAGCAAACGGTAATGCCGAGACATCCGGGGAAGGAAATACCGGAACCGCTGAGGAAGGCAATTCTTAAGC
AACTCGGTATCAAATAA
GTGAAGCAAAGCGAGTTGAGGCGTTGGCTTGCAGCTCAAGGGGCAGAATTTAAAGATGGTACTAACCACTTGAAAATCTA
TCTCAACGGCAAGCAAACGGTAATGCCGAGACATCCGGGGAAGGAAATACCGGAACCGCTGAGGAAGGCAATTCTTAAGC
AACTCGGTATCAAATAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13791.44 Da Isoelectric Point: 4.7511
>AT155347 WP_001285482.1 NZ_CP051849:4243554-4243928 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT155347 NZ_CP068798:c3283655-3283248 [Klebsiella pneumoniae]
ATGCGATACCCGGTAATTTTTGAGCATGACGAAACCGGCTGGGCGGTATTCTTTCCGGATATCCCAGAGGCAATGACGGG
AGGAGAGACCAGGGAGGAAGCGTTAGAAATGGCGCAAGATGCCCTGGTGACGGCGTTTGATTTTTACTTTGACGACCGCC
GGGAGATTCCCGCTCCATCAGCAGAAGGTGATGCGTTTGTTGAGGTTCCGGCCAGCGTGGCAGCTAAAGTATTGCTGTTA
AACCGTCTGGTCAGCACCAACACCAGCAATGCTGATCTCGCCCGCTTGATTAACACGCGCCCACAGGAAGTGCAGCGCAT
CGTGTCTCTTGGTCACAGTACCAAAATCGATACGATCCAAAAAGCGCTATCAGCGTTGGGGCAAAAGATGGAAATTGTCG
TCCACTAA
ATGCGATACCCGGTAATTTTTGAGCATGACGAAACCGGCTGGGCGGTATTCTTTCCGGATATCCCAGAGGCAATGACGGG
AGGAGAGACCAGGGAGGAAGCGTTAGAAATGGCGCAAGATGCCCTGGTGACGGCGTTTGATTTTTACTTTGACGACCGCC
GGGAGATTCCCGCTCCATCAGCAGAAGGTGATGCGTTTGTTGAGGTTCCGGCCAGCGTGGCAGCTAAAGTATTGCTGTTA
AACCGTCTGGTCAGCACCAACACCAGCAATGCTGATCTCGCCCGCTTGATTAACACGCGCCCACAGGAAGTGCAGCGCAT
CGTGTCTCTTGGTCACAGTACCAAAATCGATACGATCCAAAAAGCGCTATCAGCGTTGGGGCAAAAGATGGAAATTGTCG
TCCACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|