Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4190145..4190740 Replicon chromosome
Accession NZ_CP051765
Organism Escherichia coli strain SCU-113

Toxin (Protein)


Gene name chpB Uniprot ID A0A3L3YDL1
Locus tag HHJ30_RS19995 Protein ID WP_000239576.1
Coordinates 4190145..4190495 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HHJ30_RS20000 Protein ID WP_001223208.1
Coordinates 4190489..4190740 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ30_RS19975 4185591..4186613 - 1023 WP_001296689.1 ABC transporter permease -
HHJ30_RS19980 4186627..4188129 - 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
HHJ30_RS19985 4188269..4189225 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HHJ30_RS19990 4189535..4190065 + 531 WP_000055075.1 inorganic diphosphatase -
HHJ30_RS19995 4190145..4190495 - 351 WP_000239576.1 endoribonuclease toxin ChpB Toxin
HHJ30_RS20000 4190489..4190740 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HHJ30_RS20005 4190952..4191293 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HHJ30_RS20010 4191296..4195075 - 3780 WP_000060927.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12566.53 Da        Isoelectric Point: 6.2232

>T155320 WP_000239576.1 NZ_CP051765:c4190495-4190145 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPIRQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T155320 NZ_CP068796:3008237-3008344 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACTTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT155320 WP_001223208.1 NZ_CP051765:c4190740-4190489 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT155320 NZ_CP068796:c3008189-3008123 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L3YDL1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References