Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3441716..3442334 Replicon chromosome
Accession NZ_CP051765
Organism Escherichia coli strain SCU-113

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HHJ30_RS16465 Protein ID WP_001291435.1
Coordinates 3442116..3442334 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E9TLB8
Locus tag HHJ30_RS16460 Protein ID WP_000344794.1
Coordinates 3441716..3442090 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ30_RS16450 3436805..3437998 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HHJ30_RS16455 3438021..3441170 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HHJ30_RS16460 3441716..3442090 + 375 WP_000344794.1 Hha toxicity modulator TomB Antitoxin
HHJ30_RS16465 3442116..3442334 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HHJ30_RS16470 3442505..3443056 + 552 WP_000102564.1 maltose O-acetyltransferase -
HHJ30_RS16475 3443172..3443642 + 471 WP_000136192.1 YlaC family protein -
HHJ30_RS16480 3443806..3445356 + 1551 WP_114747478.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HHJ30_RS16485 3445398..3445751 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HHJ30_RS16495 3446130..3446441 + 312 WP_000409911.1 MGMT family protein -
HHJ30_RS16500 3446472..3447044 - 573 WP_000779826.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T155317 WP_001291435.1 NZ_CP051765:3442116-3442334 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T155317 NZ_CP068796:2287700-2287803 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14527.36 Da        Isoelectric Point: 4.9284

>AT155317 WP_000344794.1 NZ_CP051765:3441716-3442090 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGRVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT155317 NZ_CP068796:c2287841-2287570 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References