Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4472609..4473221 Replicon chromosome
Accession NZ_CP051753
Organism Escherichia coli strain SCU-102

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag HHJ21_RS21140 Protein ID WP_000833473.1
Coordinates 4473036..4473221 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5F1W1Z0
Locus tag HHJ21_RS21135 Protein ID WP_000499743.1
Coordinates 4472609..4473019 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ21_RS21120 4468121..4468936 - 816 WP_000891819.1 AraC family transcriptional regulator -
HHJ21_RS21125 4469162..4470562 + 1401 WP_000204821.1 MFS transporter -
HHJ21_RS21130 4470573..4472537 + 1965 WP_001026888.1 glycoside hydrolase family 127 protein -
HHJ21_RS21135 4472609..4473019 - 411 WP_000499743.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HHJ21_RS21140 4473036..4473221 - 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
HHJ21_RS21145 4473687..4474766 + 1080 WP_000061476.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
HHJ21_RS21150 4474807..4476345 - 1539 WP_000183978.1 aldehyde dehydrogenase AldB -
HHJ21_RS21155 4476546..4477697 - 1152 WP_000741506.1 L-threonine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T155301 WP_000833473.1 NZ_CP051753:c4473221-4473036 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

>T155301 NZ_CP068795:3589400-3589618 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15213.09 Da        Isoelectric Point: 4.5486

>AT155301 WP_000499743.1 NZ_CP051753:c4473019-4472609 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGA

Download         Length: 411 bp

>AT155301 NZ_CP068795:3589000-3589374 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A5F1W1Z0

References