Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4334585..4335216 Replicon chromosome
Accession NZ_CP051753
Organism Escherichia coli strain SCU-102

Toxin (Protein)


Gene name hicA Uniprot ID A0A792T3R5
Locus tag HHJ21_RS20555 Protein ID WP_001260302.1
Coordinates 4334941..4335216 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IZA1
Locus tag HHJ21_RS20550 Protein ID WP_000593557.1
Coordinates 4334585..4334944 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ21_RS20525 4330717..4331661 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
HHJ21_RS20530 4331658..4332491 + 834 WP_001008957.1 nickel ABC transporter permease subunit NikC -
HHJ21_RS20535 4332491..4333255 + 765 WP_001136200.1 nickel import ATP-binding protein NikD -
HHJ21_RS20540 4333252..4334058 + 807 WP_000173688.1 nickel import ATP-binding protein NikE -
HHJ21_RS20545 4334064..4334465 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
HHJ21_RS20550 4334585..4334944 - 360 WP_000593557.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HHJ21_RS20555 4334941..4335216 - 276 WP_001260302.1 type II toxin-antitoxin system HicA family toxin Toxin
HHJ21_RS20560 4335289..4336413 - 1125 WP_001366710.1 ABC transporter permease -
HHJ21_RS20565 4336413..4339148 - 2736 WP_000149100.1 ribosome-associated ATPase/putative transporter RbbA -
HHJ21_RS20570 4339145..4340212 - 1068 WP_000361507.1 HlyD family efflux transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4285963..4339148 53185


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10177.85 Da        Isoelectric Point: 10.6128

>T155300 WP_001260302.1 NZ_CP051753:c4335216-4334941 [Escherichia coli]
MRTQVQALRKKQKNTLDQIVKSHVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T155300 NZ_CP068795:c2928219-2927836 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13389.28 Da        Isoelectric Point: 5.1987

>AT155300 WP_000593557.1 NZ_CP051753:c4334944-4334585 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLTNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT155300 NZ_CP068795:c2928680-2928300 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A792T3R5

Antitoxin

Source ID Structure
AlphaFold DB L4IZA1

References