Detailed information of TA system TA155287

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2119078..2119716
• Replicon: chromosome
• Accession: NZ_CP051753
• Organism: Escherichia coli strain SCU-102

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A792T4N9
• Locus tag: HHJ21_RS09910
• Protein ID: WP_000813798.1
• Coordinates: 2119078..2119254 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HHJ21_RS09915
• Protein ID: WP_001270286.1
• Coordinates: 2119300..2119716 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ21_RS09890	2114700..2115911	-	1212	WP_071526537.1	BenE family transporter YdcO	-
HHJ21_RS09895	2115964..2116500	+	537	WP_000429508.1	DNA-binding transcriptional regulator SutR	-
HHJ21_RS09900	2116573..2118534	+	1962	WP_024177865.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
HHJ21_RS09905	2118626..2118856	-	231	WP_000494241.1	YncJ family protein	-
HHJ21_RS09910	2119078..2119254	+	177	WP_000813798.1	hypothetical protein	Toxin
HHJ21_RS09915	2119300..2119716	+	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
HHJ21_RS09920	2119795..2121201	+	1407	WP_000760631.1	PLP-dependent aminotransferase family protein	-
HHJ21_RS09925	2121446..2122591	+	1146	WP_000047443.1	ABC transporter substrate-binding protein	-
HHJ21_RS09930	2122609..2123622	+	1014	WP_000220411.1	ABC transporter ATP-binding protein	-
HHJ21_RS09935	2123623..2124564	+	942	WP_001251315.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6635.66 Da
• Isoelectric Point: 10.9293

>T155287 WP_000813798.1 NZ_CP051753:2119078-2119254 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLSFHGRRSVMPRLPSEEIKEPLHKAILKQLGLS

Nucleotide

• Length: 177 bp

>T155287 NZ_CP068795:c704384-703920 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT155287 WP_001270286.1 NZ_CP051753:2119300-2119716 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT155287 NZ_CP068795:c704719-704384 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A792T4N9