Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1094995..1095613 Replicon chromosome
Accession NZ_CP051753
Organism Escherichia coli strain SCU-102

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HHJ21_RS05035 Protein ID WP_001291435.1
Coordinates 1094995..1095213 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HHJ21_RS05040 Protein ID WP_000344800.1
Coordinates 1095239..1095613 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ21_RS05000 1090284..1090856 + 573 WP_000779829.1 YbaY family lipoprotein -
HHJ21_RS05005 1090887..1091198 - 312 WP_000409911.1 MGMT family protein -
HHJ21_RS05015 1091577..1091930 + 354 WP_000878140.1 DUF1428 domain-containing protein -
HHJ21_RS05020 1091972..1093522 - 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HHJ21_RS05025 1093686..1094156 - 471 WP_000136192.1 YlaC family protein -
HHJ21_RS05030 1094272..1094823 - 552 WP_000102564.1 maltose O-acetyltransferase -
HHJ21_RS05035 1094995..1095213 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HHJ21_RS05040 1095239..1095613 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HHJ21_RS05045 1096159..1099308 - 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
HHJ21_RS05050 1099331..1100524 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T155282 WP_001291435.1 NZ_CP051753:c1095213-1094995 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T155282 NZ_CP068791:416855-417208 [Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539]
ATGGTAAGCGATTATGTCCCGGACGCTGGGCATCTGGTGTGGCTCAACTTCACACCTCAGGCAGGGCATGAACAGGGGGG
ACGGCGACCGGCGCTGGTGCTTTCGCCTGCCGCTTATAACGGCGTCACTGGACTGATGCAGGCGTGTCCGGTGACCAGCC
GCGCCAAGGGGTATCCGTTTGAAGTGACGCTCCCTGCTCACCTTGGAGTCAGCGGCGTGGTGCTGGCCGACCATTGCCGC
AGCCTCGACTGGCGCAGTCGCCGGGCCGAACAACTTGCGGAGGCGCCGGCGGACGTCCTGGCCGAAGTCCGTGGCAAGTT
GGGCAGCTTGCTGGGCATGTCCGAGAAGGCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT155282 WP_000344800.1 NZ_CP051753:c1095613-1095239 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT155282 NZ_CP068791:416619-416861 [Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539]
ATGACGAGTCAAATTCAGAAATGGGGCAACAGCCTCGCGCTCCGCATTCCCAAAGCTCTGGCGCAGCAGGTGGGACTGAC
GCAGAGTTCAGAAGTGGAGCTGCTTCTTCAGGACGGTCAGATTGTCATCCGGCCAGTTCCTGCTCGGCAGTACGATCTCG
CCGCGCTGCTGGCCGAAATGACACCTGAAAATCTGCATGGGGAAACAGACTGGGGCGCACTGGAAGGACGCGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References