155281

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 892415..893121 Replicon chromosome
Accession NZ_CP051753
Organism Escherichia coli strain SCU-102

Toxin (Protein)


Gene name ypjF Uniprot ID A0A792X6Y0
Locus tag HHJ21_RS04100 Protein ID WP_000793497.1
Coordinates 892753..893121 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A792X4D2
Locus tag HHJ21_RS04095 Protein ID WP_000070398.1
Coordinates 892415..892756 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ21_RS04070 887516..887839 + 324 Protein_785 transposase -
HHJ21_RS04075 887979..889712 - 1734 WP_000275005.1 AAA family ATPase -
HHJ21_RS04080 890141..891229 + 1089 Protein_787 IS3 family transposase -
HHJ21_RS04085 891688..892167 + 480 WP_001118831.1 DNA repair protein RadC -
HHJ21_RS04090 892176..892397 + 222 WP_000691980.1 DUF987 family protein -
HHJ21_RS04095 892415..892756 + 342 WP_000070398.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ21_RS04100 892753..893121 + 369 WP_000793497.1 TA system toxin CbtA family protein Toxin
HHJ21_RS04105 893331..893489 - 159 Protein_792 integrase -
HHJ21_RS04110 893502..894053 + 552 Protein_793 SDR family oxidoreductase -
HHJ21_RS04115 894221..894499 + 279 WP_024177850.1 hypothetical protein -
HHJ21_RS04120 895190..896074 - 885 WP_001119038.1 LysR family transcriptional regulator -
HHJ21_RS04125 896340..897398 + 1059 WP_122986710.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC 860123..935861 75738


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13698.96 Da        Isoelectric Point: 8.7174

>T155281 WP_000793497.1 NZ_CP051753:892753-893121 [Escherichia coli]
MKNLPATISRAAKPCLSPVAIWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRNGF
TSQVQAPYLTATDILQARKACGLMSRCSYREVSNIVLSRSRL

Download         Length: 369 bp

>T155281 NZ_CP068771:c4510285-4509941 [Serratia plymuthica]
ATGTGGCAAGTCGTAACCGTCGAACGATTCGACGACGGGTTTTTATCACTGAACGGCGATGAACAAAAAAGCGTGTTGGC
GGAAATATTCAAATTGCAGGAATTCGGCCCGCTATTGGCTCGTCCGCATGCCGACACTCTGCATTTTTCCAGCTCAATAA
GGCATCTTAAAGAGCTGCGTATTCAGCACCGCGGTCGCCCGTTTCGGGTGTTTTTCGCCTTTGATCCGCAACACCTGGCC
GTACTGCTATGCGGTGGTGACAAGACAGGCGATAAACGCTTTTATCAGCGCCTGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCGACCCAGAGGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12734.47 Da        Isoelectric Point: 6.9463

>AT155281 WP_000070398.1 NZ_CP051753:892415-892756 [Escherichia coli]
MSNPTWGLQRDITPCLGARLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPPQRKQISREQT

Download         Length: 342 bp

>AT155281 NZ_CP068771:c4509935-4509633 [Serratia plymuthica]
ATGGCCAAGCCTTTATCAAATTTGATCGATAAGCTCGATCCCACCGTCGTTGCGGCAGCCCGGCAAAAGGCGGAGAAGGA
AATTTTTGAATTGCGACTGGCGATGCTGCGGGAAGAACTTGCGGTGTCTCAGGTAGAACTGGCGAAACGGCTTGGCATCA
GCCAGCCGTCGGTCGCCAATCTGGAAAAGCGCGGTAGCGAAATCAAACTCTCTTCACTGAAACGCTACATTGAAGCCATG
GGCGGCACGCTTTCGTTAGAGGTTGAACTGCCCAACGGCCAGCATCGGCGGATGACACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A792X6Y0

Antitoxin

Source ID Structure
AlphaFold DB A0A792X4D2

References