Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 625487..626037 Replicon chromosome
Accession NZ_CP051753
Organism Escherichia coli strain SCU-102

Toxin (Protein)


Gene name ccdB Uniprot ID A0A7A0MYA0
Locus tag HHJ21_RS02880 Protein ID WP_001160967.1
Coordinates 625723..626037 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag HHJ21_RS02875 Protein ID WP_000125566.1
Coordinates 625487..625720 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ21_RS02850 620560..620847 + 288 WP_000203740.1 ferredoxin-like protein FixX -
HHJ21_RS02855 620906..622237 + 1332 WP_001183197.1 MFS transporter -
HHJ21_RS02860 622345..622875 + 531 WP_000600723.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
HHJ21_RS02865 622868..624730 + 1863 WP_000377111.1 glutathione-regulated potassium-efflux system protein KefC -
HHJ21_RS02870 624922..625401 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
HHJ21_RS02875 625487..625720 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HHJ21_RS02880 625723..626037 + 315 WP_001160967.1 CcdB family protein Toxin
HHJ21_RS02885 626034..626882 - 849 WP_000257196.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
HHJ21_RS02890 626889..627266 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
HHJ21_RS02895 627269..628090 - 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HHJ21_RS02900 628087..629076 - 990 WP_000241266.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
HHJ21_RS02905 629076..630362 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11672.68 Da        Isoelectric Point: 8.0406

>T155279 WP_001160967.1 NZ_CP051753:625723-626037 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRSIVIPLTPIERFIRIRPPERLNTILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T155279 NZ_CP068771:c3865304-3865065 [Serratia plymuthica]
ATGGCAATTTATGACTACCTGGAAACAAAGAATCCGGCCGCAGCTATAGAAATTGATAGCTTGATTTCAGCGGCTGCGAC
ACCACTCTCACAAAACCCGTCCAGTGGAAAACCAGGCCGAGTGCCCGGTACACGTGAAATGGTCATTCATCATTCCTATT
TTCTGGTTTATGAATTAACCAATGGGTTAATCATTATGCTGGCCGTAGTTCATGCCCGCCGTCAGTGGCCCGCCAATTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT155279 WP_000125566.1 NZ_CP051753:625487-625720 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT155279 NZ_CP068771:c3865636-3865367 [Serratia plymuthica]
ATGTCTGAATCTACCGTAGTTATCCGAGTGGATGAGGAATTAAAAATCGCCTTTGCCAGCGCGGCCAAAGCAGCTGATCG
CACCGCATCTCAGTTGCTGCGCGATTTCATGCGTGATTTTGTCAGCCGGCAAACTCATCAGAAAGAATATGAGCAGTGGC
TACAGGAAAAAGTGGACTTAAGCCGTAAAGCGCTTAATGAAGGAAAAATTACTGATAATGAAGCAGTTGAGACCTACTTC
GCTGAACGCAGGTCAAAACTGATAAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7A0MYA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References