Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 402860..403382 Replicon chromosome
Accession NZ_CP051753
Organism Escherichia coli strain SCU-102

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag HHJ21_RS01865 Protein ID WP_001105433.1
Coordinates 403092..403382 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag HHJ21_RS01860 Protein ID WP_000212715.1
Coordinates 402860..403102 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ21_RS01840 398654..400002 + 1349 WP_100190663.1 IS3 family transposase -
HHJ21_RS01845 400102..400653 - 552 WP_000166295.1 ribosome-associated protein -
HHJ21_RS01850 400747..402099 + 1353 WP_001162171.1 metalloprotease PmbA -
HHJ21_RS01855 402282..402668 + 387 WP_001232246.1 cytochrome b562 -
HHJ21_RS01860 402860..403102 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HHJ21_RS01865 403092..403382 + 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ21_RS01870 403383..403847 - 465 WP_001106233.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HHJ21_RS01875 404005..406143 - 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
HHJ21_RS01880 406537..408192 - 1656 WP_001376150.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T155278 WP_001105433.1 NZ_CP051753:403092-403382 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T155278 NZ_CP068771:c3109492-3109160 [Serratia plymuthica]
ATGGACAGGGGGGAAATCTGGCTCGTTTCACTGGATCCGATAGCCGGTCATGAGCAAAGTGGAAAACGTCCGGTACTTAT
CGTTTCTCCAGCATCGTTTAACCAGTTGACCCGGCAACCCGTTGTTGTTCCCGTCACCAGCGGCGGAAACTTTGTTCGCA
CAGCGGGTTTTGCCGTCTCACTGGACGACTCGGGAACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGGAGCCCGGTGCGGTAGGCGACTGGAACGTATACCCGACGCTGTCGTGAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT155278 WP_000212715.1 NZ_CP051753:402860-403102 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT155278 NZ_CP068771:c3109750-3109493 [Serratia plymuthica]
ATGTATACAACTCGCCTGAAAAAGGTCGGTGGATCCGTCATGCTGGCGGTTCCTCCCGCGGTGTTGAAAACGCTGGCGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGTTGGCGCAGTGCGAGCCGCACGCCGAAATGAGCGAAGAAGATCGGGAATGGATTGATGCGCCCGCGATG
GGCAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References