Detailed information of TA system TA155277

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 389812..390407
• Replicon: chromosome
• Accession: NZ_CP051753
• Organism: Escherichia coli strain SCU-102

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: HHJ21_RS01800
• Protein ID: WP_000239581.1
• Coordinates: 390057..390407 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: HHJ21_RS01795
• Protein ID: WP_001223213.1
• Coordinates: 389812..390063 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ21_RS01785	385477..389256	+	3780	WP_042097342.1	autotransporter assembly complex protein TamB	-
HHJ21_RS01790	389259..389600	+	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
HHJ21_RS01795	389812..390063	+	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
HHJ21_RS01800	390057..390407	+	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
HHJ21_RS01805	390486..391016	-	531	WP_000055075.1	inorganic diphosphatase	-
HHJ21_RS01810	391326..392282	+	957	WP_000265935.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
HHJ21_RS01815	392415..393917	+	1503	WP_001095665.1	sugar ABC transporter ATP-binding protein	-
HHJ21_RS01820	393931..394953	+	1023	WP_001376149.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T155277 WP_000239581.1 NZ_CP051753:390057-390407 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T155277 NZ_CP068771:c2967540-2967142 [Serratia plymuthica]
ATGTTCAGCCATATGCTGGATACCAATATTGTGATTTACGTGATCAAGCGTCGGCCGCTGGAAGTGCTGGAGGCGTTCAA
TCGCTATGCCGGAAAAATGGTCATTTCGTCGATCACCTATGGCGAATTGGTTCACGGGGTGGAGAAAAGTTCGCGCCCGG
CGGTGAATGCCAGAGTGGTTGAGGATTTTGTCTCACGATTGGACATTCTCGATTACGGTGCCAAAGCGGCATCGCATTAC
GGTAACATCCGGGCTGCACTGGAACGCCAGGGAACGCCGATTGGCGTAAACGATTTGCATATCGCCGGTCATGCGCGCAG
CGAAGGTTTGATTCTTGTTAGCAATAACATGCGTGAATTTGAACCTGTCGAAGGCCTGCGTCTCGAGAATTGGTTGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT155277 WP_001223213.1 NZ_CP051753:389812-390063 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT155277 NZ_CP068771:c2967773-2967540 [Serratia plymuthica]
ATGACATTAGGTTCTGTATTTACCAATAATCGCACCCAGGCGGTGCGTTTACCTGCTGAAGTCCGCTTTCCCGATTCCGT
TTCGAAAGTCTCGGTGCGGGTGGTCGGTAAAGAGCGCATTCTTTCTCCGGTAGAAAATACCTGGGACAGTTTTTTCTGTG
CGGAAAATGAGGTGAGCGACGATTTCCTCAATGAACGTGCCGGGCAGCATCAGAGCGAGCGGGAAGATTTTTGA

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7