Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 287978..288475 Replicon chromosome
Accession NZ_CP051753
Organism Escherichia coli strain SCU-102

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag HHJ21_RS01280 Protein ID WP_001173343.1
Coordinates 288302..288475 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A2X1N3L1
Locus tag HHJ21_RS01275 Protein ID WP_001560287.1
Coordinates 287978..288274 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ21_RS01265 283335..287264 + 3930 WP_001080130.1 autotransporter outer membrane beta-barrel domain-containing protein -
HHJ21_RS01270 287477..287749 + 273 WP_000405647.1 N-acetyltransferase -
HHJ21_RS01275 287978..288274 + 297 WP_001560287.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
HHJ21_RS01280 288302..288475 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
HHJ21_RS01285 288594..290111 - 1518 WP_000003806.1 lysine--tRNA ligase -
HHJ21_RS01290 290348..291805 - 1458 WP_000856827.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 272230..297329 25099


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T155276 WP_001173343.1 NZ_CP051753:288302-288475 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T155276 NZ_CP068771:2927236-2927418 [Serratia plymuthica]
GTGAAAAGTGCAGAACTGATCAGGCTGTTAGAACGGGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
TAAACACCCGAGATCCCGTCTGGTGATCACCGTTCCACCCCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAAATCA
TGAAAGATGCCGGGCTGTGCTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11441.94 Da        Isoelectric Point: 4.2924

>AT155276 WP_001560287.1 NZ_CP051753:287978-288274 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMHDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT155276 NZ_CP068771:2927448-2927861 [Serratia plymuthica]
ATGTTCTACCCTGCTTATGTACATTCAGACCACGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGTTGCTATTT
TGCCGGCGATACCCTCGATATCGCCTTTGAAGACGCCAAAAGCGCGCTGGACGCGCATTTCGAACTGCTGAGCGAAGACA
ACCAGGCCATCCCGCGCCCACAGGCCGTTTCCTTCCATCTGGCGCAGCAAAACGACACCCTGAACGGCGGGCAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGGCGGGCGGAACGTATAAATATCACCCTGCCGCACCGCTTGCTGAACCG
CATCGATTCACTGGTGCAGCGGCATCCTGGCTATGGGAGCCGCAGCGCTTTTTTGGCCGCCGCCGCCCGTAATGAATTAT
TGAAAGTCGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1N3L1

References