Detailed information of TA system TA155273

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4280699..4281519
• Replicon: chromosome
• Accession: NZ_CP051751
• Organism: Escherichia coli strain SCU-301

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: HHJ43_RS20445
• Protein ID: WP_001054376.1
• Coordinates: 4280699..4280956 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HHJ43_RS20450
• Protein ID: WP_001519303.1
• Coordinates: 4280968..4281519 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ43_RS20425	4275985..4277091	+	1107	WP_001298082.1	N-acetylneuraminate epimerase	-
HHJ43_RS20430	4277156..4278136	+	981	WP_000991425.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
HHJ43_RS20435	4278719..4279960	-	1242	Protein_4000	helicase YjhR	-
HHJ43_RS20440	4280023..4280322	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
HHJ43_RS20445	4280699..4280956	+	258	WP_001054376.1	hypothetical protein	Toxin
HHJ43_RS20450	4280968..4281519	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
HHJ43_RS20455	4281571..4281732	+	162	WP_001519302.1	hypothetical protein	-
HHJ43_RS20460	4281769..4282317	+	549	WP_001519301.1	hypothetical protein	-
HHJ43_RS20465	4282444..4282704	+	261	WP_000084876.1	hypothetical protein	-
HHJ43_RS24140	4282742..4282858	+	117	Protein_4007	VOC family protein	-
HHJ43_RS20470	4283103..4284224	+	1122	WP_000010833.1	M42 family metallopeptidase	-
HHJ43_RS20475	4284221..4284499	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
HHJ43_RS20480	4284511..4285824	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimC / fimI / fimA / fimE / fimB	4269712..4289739	20027

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T155273 WP_001054376.1 NZ_CP051751:4280699-4280956 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T155273 NZ_CP068771:c884483-884280 [Serratia plymuthica]
ATGACTAAAATTGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACCCTGGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGACGACGAGCTGGAGCTGTTTTACTCCGCAGCCGACCATCGCCTTGCCGAGCTCACCATGAATAAGC
TGTACGATAAAATCCCTGTTGCCGTTTGGAAATTCGTAAGGTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT155273 WP_001519303.1 NZ_CP051751:4280968-4281519 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT155273 NZ_CP068771:c884898-884530 [Serratia plymuthica]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
CACGCTGGGCGACAGCCACCACGGTTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAACGAGTTGATTGAGC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTGGTCGAGGAGTATCTC
GACGATACCTACACGCTGTTTAGCAGTTACGGTATTAACGATTCCGATTTGCGCCGCTGGCAAAAAACCAAAGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAAACTTAA

Structures

Toxin

• AlphaFold DB: S1PA82