Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3683560..3684178 Replicon chromosome
Accession NZ_CP051751
Organism Escherichia coli strain SCU-301

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HHJ43_RS17645 Protein ID WP_001291435.1
Coordinates 3683960..3684178 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HHJ43_RS17640 Protein ID WP_000344800.1
Coordinates 3683560..3683934 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ43_RS17630 3678649..3679842 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HHJ43_RS17635 3679865..3683014 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
HHJ43_RS17640 3683560..3683934 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HHJ43_RS17645 3683960..3684178 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HHJ43_RS17650 3684350..3684901 + 552 WP_096986530.1 maltose O-acetyltransferase -
HHJ43_RS17655 3685017..3685487 + 471 WP_022645280.1 YlaC family protein -
HHJ43_RS17660 3685651..3687201 + 1551 WP_089583158.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HHJ43_RS17665 3687243..3687596 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HHJ43_RS17675 3687975..3688286 + 312 WP_000409911.1 MGMT family protein -
HHJ43_RS17680 3688317..3688889 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T155270 WP_001291435.1 NZ_CP051751:3683960-3684178 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T155270 NZ_CP068771:322780-323055 [Serratia plymuthica]
ATGGAAATTTACTGGACGCTTAAAGCTCAGGATGACCTGGAACGTATCTACCGTTTTGCCTTGCAGTACAGTCGCCAGCA
TGCCGATGACGTTTTAGACCGCTTGATAATCGGCAGCACCGGCCTTACGGCGCACCCGGCAATCGGCATACAGCAGACTC
GATATGAACCTCGGGAAGTTCGAAAAGTGTTATTCGATGACTACGAGGTTCACTACGAACTCCGCGACACTGCCATCTAC
ATCGTGGATCTCTGGCATACAAAAGAAGAACGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT155270 WP_000344800.1 NZ_CP051751:3683560-3683934 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT155270 NZ_CP068771:322528-322776 [Serratia plymuthica]
ATGGGTTCGCTTACTAAACAAACCATCAGCGCACAGATACCCGTTGAGTTGGCTGCTGCTGTCGAAAATCTGGCTATTGA
GTTGGACCGTTCTAAAAGCTGGATCATTAAGGAAGCCTTGACTCGTATGCTGGCCGAAAGTGAACGGCGTCACCAGAGCA
TCCAGGCCGGTCTTGCTGATGTGGATGCCGGTCGTGTAGTGAGTCATTTGGACATGGTGGATTTTGCCAATCGTTTAAAG
AAAACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References