Detailed information of TA system TA155268

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3264495..3265200
• Replicon: chromosome
• Accession: NZ_CP051751
• Organism: Escherichia coli strain SCU-301

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: HHJ43_RS15775
• Protein ID: WP_000539521.1
• Coordinates: 3264495..3264881 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HHJ43_RS15780
• Protein ID: WP_001280945.1
• Coordinates: 3264871..3265200 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ43_RS15755	3260499..3261125	+	627	WP_096986484.1	glutathione S-transferase GstB	-
HHJ43_RS15760	3261122..3262237	-	1116	WP_000555050.1	aldose sugar dehydrogenase YliI	-
HHJ43_RS15765	3262348..3262731	-	384	WP_000497137.1	biofilm formation regulator BssR	-
HHJ43_RS15770	3262944..3264269	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
HHJ43_RS15775	3264495..3264881	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHJ43_RS15780	3264871..3265200	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
HHJ43_RS15785	3265270..3266598	-	1329	WP_000086870.1	GGDEF domain-containing protein	-
HHJ43_RS15790	3266606..3268954	-	2349	WP_000950331.1	EAL domain-containing protein	-
HHJ43_RS15795	3269131..3270042	-	912	WP_001236044.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T155268 WP_000539521.1 NZ_CP051751:3264495-3264881 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T155268 NZ_CP068764:2548-2826 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT155268 WP_001280945.1 NZ_CP051751:3264871-3265200 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT155268 NZ_CP068764:2363-2548 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Structures

Toxin

• AlphaFold DB: A0A829GCT6