Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 853623..854418 Replicon chromosome
Accession NZ_CP051751
Organism Escherichia coli strain SCU-301

Toxin (Protein)


Gene name yeeV Uniprot ID A0A658LKE6
Locus tag HHJ43_RS04005 Protein ID WP_001596171.1
Coordinates 853623..853997 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A6D0GHH4
Locus tag HHJ43_RS04010 Protein ID WP_071342845.1
Coordinates 854044..854418 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ43_RS03980 849693..850676 - 984 WP_001361242.1 KpsF/GutQ family sugar-phosphate isomerase -
HHJ43_RS03985 851487..851657 - 171 Protein_782 IS110 family transposase -
HHJ43_RS03990 851999..852841 - 843 WP_042093078.1 DUF4942 domain-containing protein -
HHJ43_RS03995 852926..853123 - 198 WP_001596173.1 DUF957 domain-containing protein -
HHJ43_RS04000 853135..853626 - 492 WP_001596172.1 hypothetical protein -
HHJ43_RS04005 853623..853997 - 375 WP_001596171.1 TA system toxin CbtA family protein Toxin
HHJ43_RS04010 854044..854418 - 375 WP_071342845.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ43_RS04015 854581..854802 - 222 WP_000692323.1 DUF987 domain-containing protein -
HHJ43_RS04020 854865..855341 - 477 WP_001186726.1 RadC family protein -
HHJ43_RS04025 855356..855841 - 486 WP_073991182.1 antirestriction protein -
HHJ43_RS04030 855933..856751 - 819 WP_073991181.1 DUF945 domain-containing protein -
HHJ43_RS04035 857091..858161 - 1071 WP_021564623.1 patatin-like phospholipase family protein -
HHJ43_RS04040 858158..859063 - 906 WP_000203530.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 851487..851642 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14161.14 Da        Isoelectric Point: 6.7041

>T155254 WP_001596171.1 NZ_CP051751:c853997-853623 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLARLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYELVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T155254 NZ_CP068715:14439-14711 [Staphylococcus pseudoxylosus]
TTGAAGTATTCATTAAAAATTAGTAAAAAAACAAATAAAACTTTAAGTAAAATGGACAAGCCCACTAGAAATCTATTATT
GAAATGGATGAACAATAATATTCACAACACTGACAACCCTAGACTTCATGGAAAATCTTTACGAGGTGAGTTATCTGGCC
TTTGGAGATATAGAGTAGGTAAATATAGAATTATAGTTGAAATTCAAGATGATGAACTAGTAGTTTTAGCAATTGATGTA
GGTATAAGAGGTAGTATATATAACAAGAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13744.51 Da        Isoelectric Point: 6.4757

>AT155254 WP_071342845.1 NZ_CP051751:c854418-854044 [Escherichia coli]
VSDTLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLTVYPTPAPATTS

Download         Length: 375 bp

>AT155254 NZ_CP068715:14215-14442 [Staphylococcus pseudoxylosus]
ATGGCTACTATCACAGTAAGAGTAAGCGATGAGGAAAAAGAATTTTTAGAATATATGTCTAATTTTCTCGGACTAAGTTT
AAGTAAGATAATCAAGGAATACACTATAGAAGATTTAGAAAATATTTATGATGCTAAAGTTGGTGATGATGCTTTAAAAG
AATATCGTGAAAATGGTGAACAAGCTCTCTATATTGACGATGTAATGAAACAGTGGAATGTTAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A658LKE6

Antitoxin

Source ID Structure
AlphaFold DB A0A6D0GHH4

References