Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 307662..308293 Replicon chromosome
Accession NZ_CP051751
Organism Escherichia coli strain SCU-301

Toxin (Protein)


Gene name hicA Uniprot ID D8A4M2
Locus tag HHJ43_RS01325 Protein ID WP_001259770.1
Coordinates 307662..307937 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag HHJ43_RS01330 Protein ID WP_000593555.1
Coordinates 307934..308293 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ43_RS01310 302666..303733 + 1068 WP_096986888.1 HlyD family efflux transporter periplasmic adaptor subunit -
HHJ43_RS01315 303730..306465 + 2736 WP_096986887.1 ribosome-associated ATPase/putative transporter RbbA -
HHJ43_RS01320 306465..307589 + 1125 WP_001314210.1 ABC transporter permease -
HHJ43_RS01325 307662..307937 + 276 WP_001259770.1 type II toxin-antitoxin system HicA family toxin Toxin
HHJ43_RS01330 307934..308293 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HHJ43_RS01335 308343..309203 - 861 WP_001131792.1 class II aldolase -
HHJ43_RS01340 309235..309504 - 270 WP_000949581.1 HPr family phosphocarrier protein -
HHJ43_RS01345 309494..311002 - 1509 WP_096986886.1 carbohydrate kinase -
HHJ43_RS01350 310995..312353 - 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
HHJ43_RS01355 312427..312708 - 282 WP_000084021.1 PTS sugar transporter subunit IIB -
HHJ43_RS01360 312705..313178 - 474 WP_096986885.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10170.90 Da        Isoelectric Point: 10.6128

>T155252 WP_001259770.1 NZ_CP051751:307662-307937 [Escherichia coli]
MRTLVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T155252 NZ_CP068712:c2770356-2770261 [Staphylococcus pseudoxylosus]
ATGCTTATGATCTTCGTTCACATCATTGCACCAGTCATTAGTGATTGTGCAGTTGCGTATTTTACTTACTGGCTTAGTAG
TAAACGCAATAAATAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT155252 WP_000593555.1 NZ_CP051751:307934-308293 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT155252 NZ_CP068712:c2770235-2770206 [Staphylococcus pseudoxylosus]
AATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FQ35

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References