155251

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 168293..168905 Replicon chromosome
Accession NZ_CP051751
Organism Escherichia coli strain SCU-301

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag HHJ43_RS00740 Protein ID WP_000833473.1
Coordinates 168293..168478 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1M2IVK0
Locus tag HHJ43_RS00745 Protein ID WP_000499742.1
Coordinates 168495..168905 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ43_RS00725 163795..164946 + 1152 WP_096986798.1 L-threonine dehydrogenase -
HHJ43_RS00730 165076..166371 + 1296 WP_096986799.1 Fic family protein -
HHJ43_RS00735 166479..168017 + 1539 WP_000183978.1 aldehyde dehydrogenase AldB -
HHJ43_RS00740 168293..168478 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
HHJ43_RS00745 168495..168905 + 411 WP_000499742.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HHJ43_RS00750 169017..170996 - 1980 WP_096986800.1 glycoside hydrolase family 127 protein -
HHJ43_RS00755 171007..172407 - 1401 WP_096986801.1 MFS transporter -
HHJ43_RS00760 172633..173448 + 816 WP_000891824.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T155251 WP_000833473.1 NZ_CP051751:168293-168478 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

>T155251 NZ_CP068712:1020507-1020869 [Staphylococcus pseudoxylosus]
ATGATGAGAAGAGGAGACGTTTATTTAGCTGATTTGTCACCAGTGCAAGGGTCTGAACAAGGGGGAATTAGACCCGTCGT
TATTATACAAAACGATACTGGTAATAAATATAGTCCTACAGTAATTGTGGCTGCAATTACTGGTAGGATTAATAAAGCTA
AAATACCTACACATGTAGAAATAGAAAAAAGTAAATATAAACTTGATAAAGATTCTGTTATATTGTTAGAACAAATCAGA
ACTTTAGATAAAAATAGACTAAAAGAAAAATTAACATATCTTTCTGAGAAAAAAATGAAAGAAGTTAACATTGCTATTGA
TATAAGTTTAGGATTACATAATATTAGGAATAATAAATCCTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15242.13 Da        Isoelectric Point: 4.4482

>AT155251 WP_000499742.1 NZ_CP051751:168495-168905 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMDEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp

>AT155251 NZ_CP068712:1020340-1020510 [Staphylococcus pseudoxylosus]
ATGGCAAGTTTTAATCAAAGTAGAAACCATAGTATTGAACAACTATTAAAAGAAGGCTATTCTCAAATGGCTGACTTAAA
TCTCTCCCTTGCAGCAGAAGCCTTTCCATTTGAATGTGAAGCTTGTGATTGCAATGAAGTTTACATTAGCTCCAAGAATA
ATAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2IVK0

References