Detailed information of TA system TA155245

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4734257..4735245
• Replicon: chromosome
• Accession: NZ_CP051744
• Organism: Escherichia coli strain SCU-484

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: HHJ53_RS22710
• Protein ID: WP_014640052.1
• Coordinates: 4734257..4734643 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: HHJ53_RS22715
• Protein ID: WP_021538830.1
• Coordinates: 4734673..4735245 (-)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ53_RS22660	4729971..4730507	+	537	WP_000008177.1	5'-deoxynucleotidase	-
HHJ53_RS22665	4730498..4730860	+	363	WP_001242718.1	phage protein	-
HHJ53_RS22670	4730857..4731060	+	204	WP_000111289.1	hypothetical protein	-
HHJ53_RS22675	4731053..4731301	+	249	WP_000476209.1	hypothetical protein	-
HHJ53_RS22680	4731288..4732073	+	786	WP_021529121.1	ead/Ea22-like family protein	-
HHJ53_RS22685	4732075..4732362	+	288	WP_000212745.1	hypothetical protein	-
HHJ53_RS22690	4732366..4733106	+	741	WP_023145274.1	hypothetical protein	-
HHJ53_RS22695	4733106..4733678	+	573	WP_023145273.1	3'-5' exoribonuclease	-
HHJ53_RS22700	4733715..4733996	+	282	WP_001093916.1	pyocin activator PrtN family protein	-
HHJ53_RS22705	4734044..4734217	-	174	WP_021538831.1	hypothetical protein	-
HHJ53_RS22710	4734257..4734643	-	387	WP_014640052.1	hypothetical protein	Toxin
HHJ53_RS22715	4734673..4735245	-	573	WP_021538830.1	SocA family protein	Antitoxin
HHJ53_RS22720	4735719..4736234	+	516	WP_000416264.1	zinc uptake transcriptional repressor Zur	-
HHJ53_RS22725	4736276..4736485	-	210	WP_001296638.1	CsbD family protein	-
HHJ53_RS22730	4736601..4737926	-	1326	WP_001350407.1	MATE family efflux transporter DinF	-
HHJ53_RS22735	4737999..4738607	-	609	WP_000646078.1	transcriptional repressor LexA	-
HHJ53_RS22740	4738717..4739085	-	369	WP_000002907.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4687963..4747165	59202

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T155245 WP_014640052.1 NZ_CP051744:c4734643-4734257 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T155245 NZ_CP068708:c1958821-1958492 [Streptococcus suis]
ATGGAATTTGAGTCATATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGATATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTGGAGAGTTTGCAAATTTTTCCGGAAC
GTGGCTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCACATCTGACCCGAGGTTACGTTATTGGAAAAGAC
TACATTGCACTCTATCGTGTGGTCGAAAAAGAAGTGCGAGTTGGTCATCTCTTTGCGACTAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21987.31 Da
• Isoelectric Point: 5.6404

>AT155245 WP_021538830.1 NZ_CP051744:c4735245-4734673 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHDPGYSRKPIDLKEMLI
SEGKSEDEANHIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT155245 NZ_CP068708:c1959098-1958811 [Streptococcus suis]
TTGATAACTATAAAGAAGAATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGTTGGATTTGACTGCTGGTTTTAACCTCTTTTTACAAAACATTGCTGTAAAAAATGAGTTGCCCATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAACTTCAAAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCAAGGGATCAGCCTAGAAATCGTCAAAGAGAAGTATGGAATTTGA