Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 815274..816106 Replicon chromosome
Accession NZ_CP051744
Organism Escherichia coli strain SCU-484

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag HHJ53_RS03915 Protein ID WP_000854753.1
Coordinates 815274..815648 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag HHJ53_RS03920 Protein ID WP_001278232.1
Coordinates 815738..816106 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ53_RS03885 810388..811536 - 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -
HHJ53_RS03890 811608..812591 - 984 WP_001616958.1 KpsF/GutQ family sugar-phosphate isomerase -
HHJ53_RS03895 813402..813572 - 171 Protein_765 IS110 family transposase -
HHJ53_RS03900 813914..814483 - 570 WP_001290241.1 DUF4942 domain-containing protein -
HHJ53_RS03905 814580..814777 - 198 WP_000839281.1 DUF957 domain-containing protein -
HHJ53_RS03910 814789..815277 - 489 WP_169057840.1 hypothetical protein -
HHJ53_RS03915 815274..815648 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
HHJ53_RS03920 815738..816106 - 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HHJ53_RS03925 816269..816490 - 222 WP_000692316.1 DUF987 domain-containing protein -
HHJ53_RS03930 816553..817029 - 477 WP_001186726.1 RadC family protein -
HHJ53_RS03935 817045..817530 - 486 WP_001520165.1 antirestriction protein -
HHJ53_RS03940 817585..818403 - 819 WP_169057841.1 DUF945 domain-containing protein -
HHJ53_RS03945 818503..818736 - 234 WP_001119729.1 DUF905 family protein -
HHJ53_RS03950 818815..819270 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T155222 WP_000854753.1 NZ_CP051744:c815648-815274 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T155222 NZ_CP068706:2139235-2139522 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT155222 WP_001278232.1 NZ_CP051744:c816106-815738 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT155222 NZ_CP068706:2138996-2139235 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References