Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 131182..131729 Replicon plasmid pSCU-105-1
Accession NZ_CP051739
Organism Escherichia coli strain SCU-105

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HHJ23_RS25460 Protein ID WP_169063293.1
Coordinates 131182..131463 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HHJ23_RS25465 Protein ID WP_169063294.1
Coordinates 131460..131729 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ23_RS25435 126274..126708 - 435 WP_169063308.1 hypothetical protein -
HHJ23_RS25440 126972..127238 - 267 WP_169063309.1 hypothetical protein -
HHJ23_RS25445 128116..129453 + 1338 WP_169063292.1 amino acid permease -
HHJ23_RS25450 129707..129952 - 246 Protein_153 IS4 family transposase -
HHJ23_RS25455 130305..131136 - 832 Protein_154 3'-5' exonuclease -
HHJ23_RS25460 131182..131463 - 282 WP_169063293.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ23_RS25465 131460..131729 - 270 WP_169063294.1 hypothetical protein Antitoxin
HHJ23_RS25470 131812..132022 + 211 Protein_157 ISKra4 family transposase -
HHJ23_RS25475 132389..132625 - 237 WP_169063295.1 hypothetical protein -
HHJ23_RS25480 132832..133287 - 456 WP_169063296.1 hypothetical protein -
HHJ23_RS25490 134576..135061 - 486 WP_169063297.1 LysR family transcriptional regulator -
HHJ23_RS25495 135156..135665 + 510 WP_169063298.1 phenolic acid decarboxylase -
HHJ23_RS25500 135678..136724 + 1047 WP_169063299.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul2 / aph(3'')-Ib / aph(6)-Id faeJ / faeI / faeH / faeF / faeE / faeD / faeC 1..172627 172627
- inside IScluster/Tn - - 125179..134500 9321


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10978.68 Da        Isoelectric Point: 9.4120

>T155219 WP_169063293.1 NZ_CP051739:c131463-131182 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLARQPYKGRNGRVEGSRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T155219 NZ_CP068706:1696111-1696365 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10194.55 Da        Isoelectric Point: 8.8735

>AT155219 WP_169063294.1 NZ_CP051739:c131729-131460 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLGRGDILPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT155219 NZ_CP068706:1695863-1696114 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References