Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 49308..50083 | Replicon | plasmid pSCU-105-1 |
Accession | NZ_CP051739 | ||
Organism | Escherichia coli strain SCU-105 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | A0A6D0V6Q2 |
Locus tag | HHJ23_RS24950 | Protein ID | WP_000405252.1 |
Coordinates | 49308..49790 (-) | Length | 161 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | - |
Locus tag | HHJ23_RS24955 | Protein ID | WP_001346256.1 |
Coordinates | 49781..50083 (-) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HHJ23_RS24920 | 45002..45793 | - | 792 | Protein_55 | incFII family plasmid replication initiator RepA | - |
HHJ23_RS24925 | 45987..47528 | + | 1542 | WP_001298859.1 | IS21-like element ISEc12 family transposase | - |
HHJ23_RS24930 | 47543..48289 | + | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
HHJ23_RS24935 | 48371..48445 | - | 75 | Protein_58 | replication protein RepA | - |
HHJ23_RS24940 | 48438..48512 | - | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
HHJ23_RS24945 | 48750..49004 | - | 255 | WP_000083846.1 | replication regulatory protein RepA | - |
HHJ23_RS24950 | 49308..49790 | - | 483 | WP_000405252.1 | GNAT family N-acetyltransferase | Toxin |
HHJ23_RS24955 | 49781..50083 | - | 303 | WP_001346256.1 | DUF1778 domain-containing protein | Antitoxin |
HHJ23_RS24960 | 50292..50553 | - | 262 | Protein_63 | type I toxin-antitoxin system Hok family toxin | - |
- | 50606..50657 | + | 52 | NuclAT_1 | - | - |
- | 50606..50657 | + | 52 | NuclAT_1 | - | - |
- | 50606..50657 | + | 52 | NuclAT_1 | - | - |
- | 50606..50657 | + | 52 | NuclAT_1 | - | - |
HHJ23_RS24965 | 50756..51003 | - | 248 | Protein_64 | DUF2726 domain-containing protein | - |
HHJ23_RS24970 | 51492..51704 | - | 213 | WP_049035740.1 | ANR family transcriptional regulator | - |
HHJ23_RS24975 | 51835..52395 | - | 561 | WP_169063274.1 | fertility inhibition protein FinO | - |
HHJ23_RS24980 | 52450..53196 | - | 747 | WP_000205718.1 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | sul2 / aph(3'')-Ib / aph(6)-Id | faeJ / faeI / faeH / faeF / faeE / faeD / faeC | 1..172627 | 172627 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 17687.47 Da Isoelectric Point: 7.1036
>T155214 WP_000405252.1 NZ_CP051739:c49790-49308 [Escherichia coli]
MEINVTAPVLLTDEHILQPFDCGNEVLSNWLHGRAMKNQMLNASRTFVICLEGTLRVVGYYSLATGSVTHAELGRSLRHN
MPNPVPVVLLGRLAVDVCTQGHGFGKWLLSDAIHRVVNLADQVGIKAVMVHAIDDDARAFYERFGFVQSVVAPNTLFYKV
MEINVTAPVLLTDEHILQPFDCGNEVLSNWLHGRAMKNQMLNASRTFVICLEGTLRVVGYYSLATGSVTHAELGRSLRHN
MPNPVPVVLLGRLAVDVCTQGHGFGKWLLSDAIHRVVNLADQVGIKAVMVHAIDDDARAFYERFGFVQSVVAPNTLFYKV
Download Length: 483 bp
>T155214 NZ_CP068706:742199-742606 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11602.19 Da Isoelectric Point: 4.4569
>AT155214 WP_001346256.1 NZ_CP051739:c50083-49781 [Escherichia coli]
MEVVMPTTASIRKTPRENQINIRATDEERAVIDYAASLVNKNRTDFIIELAYQEAKNIILDQRLFVLDDECYDSFITQLE
APVQNAEGRERLMAVKPEWK
MEVVMPTTASIRKTPRENQINIRATDEERAVIDYAASLVNKNRTDFIIELAYQEAKNIILDQRLFVLDDECYDSFITQLE
APVQNAEGRERLMAVKPEWK
Download Length: 303 bp
>AT155214 NZ_CP068706:741952-742218 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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