Detailed information of TA system TA155210

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 4552480..4553075
• Replicon: chromosome
• Accession: NZ_CP051738
• Organism: Escherichia coli strain SCU-105

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: HHJ23_RS21820
• Protein ID: WP_000239581.1
• Coordinates: 4552480..4552830 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: HHJ23_RS21825
• Protein ID: WP_001223213.1
• Coordinates: 4552824..4553075 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ23_RS21800	4547927..4548949	-	1023	WP_001367697.1	ABC transporter permease	-
HHJ23_RS21805	4548963..4550465	-	1503	WP_000205837.1	sugar ABC transporter ATP-binding protein	-
HHJ23_RS21810	4550605..4551561	-	957	WP_000265933.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
HHJ23_RS21815	4551871..4552401	+	531	WP_000055075.1	inorganic diphosphatase	-
HHJ23_RS21820	4552480..4552830	-	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
HHJ23_RS21825	4552824..4553075	-	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
HHJ23_RS21830	4553287..4553628	-	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
HHJ23_RS21835	4553631..4557410	-	3780	WP_169063245.1	autotransporter assembly complex protein TamB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T155210 WP_000239581.1 NZ_CP051738:c4552830-4552480 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T155210 NZ_CP068697:56376-56681 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGTCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT155210 WP_001223213.1 NZ_CP051738:c4553075-4552824 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT155210 NZ_CP068697:56156-56374 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7