Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4541129..4541651 Replicon chromosome
Accession NZ_CP051738
Organism Escherichia coli strain SCU-105

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag HHJ23_RS21760 Protein ID WP_001105433.1
Coordinates 4541129..4541419 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D8WJ36
Locus tag HHJ23_RS21765 Protein ID WP_000212718.1
Coordinates 4541409..4541651 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ23_RS21745 4536297..4537952 + 1656 WP_001577606.1 alpha,alpha-phosphotrehalase -
HHJ23_RS21750 4538346..4540484 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
HHJ23_RS21755 4540664..4541128 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HHJ23_RS21760 4541129..4541419 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ23_RS21765 4541409..4541651 - 243 WP_000212718.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HHJ23_RS21770 4541843..4542229 - 387 WP_001232253.1 cytochrome b562 -
HHJ23_RS21775 4542285..4543637 - 1353 WP_001162171.1 metalloprotease PmbA -
HHJ23_RS21780 4543731..4544282 + 552 WP_000166270.1 ribosome-associated protein -
HHJ23_RS21785 4544365..4545738 - 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-66)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T155209 WP_001105433.1 NZ_CP051738:c4541419-4541129 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T155209 NZ_CP068697:c29095-28697 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTGAAGTTTATGCTGGATACTAACATCTGCATTTTCACGATAAAAAACAAACCTGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGCTCGGTCACCCTGATGGAGCTGATTTACGGCGCCGAAAAAAGCCAGATGCCCG
AAAGAAATCTCGCTGTGATAGAGGGGTTTGTTTCCCGACTTGATGTTCTGGATTATGACACGCCGGCCGCCACCCATACG
GGGCAGATCAGGGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTCGATCAGATGATTGCCGGTCACGCACGCAG
CCGGGGACTGATTGTTGTCACGAACAACACCCGGGAGTTTGAACGTGTGGGTGGACTGAGAACTGAGGACTGGAGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9174.63 Da        Isoelectric Point: 5.1369

>AT155209 WP_000212718.1 NZ_CP051738:c4541651-4541409 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLAYPQEAIKVRLDEL

Download         Length: 243 bp

>AT155209 NZ_CP068697:c29322-29095 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGAAACCAGCGTATTTCTCAGTAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCAGTGGCTTTGCCGGAAAATGTAAA
ACGTGTGGAAGTTATCGCTGTCGGGCGAACCCGAATTATCACGCCGGCCGGAGAATCGTGGGATGAATGGTTCGACGGGA
ACAACGTCAGCGCCGATTTTATGGATAACCGGGAACAACCCTCTGTGCAGGAACGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8WJ36

References