Detailed information of TA system TA155205

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3406571..3407276
• Replicon: chromosome
• Accession: NZ_CP051738
• Organism: Escherichia coli strain SCU-105

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: HHJ23_RS16530
• Protein ID: WP_000539521.1
• Coordinates: 3406571..3406957 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HHJ23_RS16535
• Protein ID: WP_001280945.1
• Coordinates: 3406947..3407276 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ23_RS16510	3402575..3403201	+	627	WP_001314584.1	glutathione S-transferase GstB	-
HHJ23_RS16515	3403198..3404313	-	1116	WP_000555033.1	aldose sugar dehydrogenase YliI	-
HHJ23_RS16520	3404424..3404807	-	384	WP_000497137.1	biofilm formation regulator BssR	-
HHJ23_RS16525	3405020..3406345	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
HHJ23_RS16530	3406571..3406957	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHJ23_RS16535	3406947..3407276	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
HHJ23_RS16540	3407346..3408674	-	1329	WP_000086879.1	GGDEF domain-containing protein	-
HHJ23_RS16545	3408682..3411030	-	2349	WP_001322378.1	EAL domain-containing protein	-
HHJ23_RS16550	3411208..3412119	-	912	WP_001236042.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T155205 WP_000539521.1 NZ_CP051738:3406571-3406957 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T155205 NZ_CP068696:4183019-4183294 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT155205 WP_001280945.1 NZ_CP051738:3406947-3407276 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT155205 NZ_CP068696:c4183284-4182862 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A829GCT6