Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3237589..3238424 Replicon chromosome
Accession NZ_CP051738
Organism Escherichia coli strain SCU-105

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HHJ23_RS15705 Protein ID WP_032186260.1
Coordinates 3237589..3237966 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HHJ23_RS15710 Protein ID WP_032186258.1
Coordinates 3238056..3238424 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ23_RS15675 3234266..3234970 + 705 WP_001241678.1 leucyl/phenylalanyl-tRNA--protein transferase -
HHJ23_RS15680 3235255..3235473 + 219 WP_001040187.1 translation initiation factor IF-1 -
HHJ23_RS15690 3235964..3236805 - 842 Protein_3074 DUF4942 domain-containing protein -
HHJ23_RS15695 3236890..3237084 - 195 WP_032186262.1 DUF957 domain-containing protein -
HHJ23_RS15700 3237104..3237592 - 489 WP_032186261.1 hypothetical protein -
HHJ23_RS15705 3237589..3237966 - 378 WP_032186260.1 TA system toxin CbtA family protein Toxin
HHJ23_RS15710 3238056..3238424 - 369 WP_032186258.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ23_RS15715 3238587..3238808 - 222 WP_000692329.1 DUF987 domain-containing protein -
HHJ23_RS15720 3238871..3239347 - 477 WP_032186257.1 RadC family protein -
HHJ23_RS15725 3239363..3239848 - 486 WP_032186255.1 antirestriction protein -
HHJ23_RS15730 3239903..3240721 - 819 WP_072855048.1 DUF945 domain-containing protein -
HHJ23_RS15735 3240821..3241054 - 234 WP_001119729.1 DUF905 family protein -
HHJ23_RS15740 3241133..3241588 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14077.07 Da        Isoelectric Point: 7.8045

>T155204 WP_032186260.1 NZ_CP051738:c3237966-3237589 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKR

Download         Length: 378 bp

>T155204 NZ_CP068696:3981765-3981983 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13474.28 Da        Isoelectric Point: 5.9574

>AT155204 WP_032186258.1 NZ_CP051738:c3238424-3238056 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLIKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT155204 NZ_CP068696:3981363-3981737 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References