Detailed information of TA system TA155203

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3004620..3005464
• Replicon: chromosome
• Accession: NZ_CP051738
• Organism: Escherichia coli strain SCU-105

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: HHJ23_RS14630
• Protein ID: WP_000854686.1
• Coordinates: 3004620..3005003 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0J1S3
• Locus tag: HHJ23_RS14635
• Protein ID: WP_001285602.1
• Coordinates: 3005084..3005464 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ23_RS14590	2999622..3000113	-	492	WP_001309402.1	DUF1097 domain-containing protein	-
HHJ23_RS14595	3000215..3000769	-	555	WP_001001909.1	molecular chaperone YcdY	-
HHJ23_RS14600	3000793..3001530	-	738	WP_169063192.1	zinc-binding phosphatase	-
HHJ23_RS14605	3001585..3002523	-	939	WP_000351282.1	glyoxylate/hydroxypyruvate reductase GhrA	-
HHJ23_RS14615	3002994..3003836	-	843	WP_001431817.1	DUF4942 domain-containing protein	-
HHJ23_RS14620	3003921..3004118	-	198	WP_000839253.1	DUF957 domain-containing protein	-
HHJ23_RS14625	3004135..3004623	-	489	WP_001054233.1	hypothetical protein	-
HHJ23_RS14630	3004620..3005003	-	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
HHJ23_RS14635	3005084..3005464	-	381	WP_001285602.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HHJ23_RS14640	3005475..3006158	-	684	WP_000086768.1	hypothetical protein	-
HHJ23_RS14645	3006177..3006398	-	222	WP_000692298.1	DUF987 domain-containing protein	-
HHJ23_RS14650	3006461..3006937	-	477	WP_169063193.1	RadC family protein	-
HHJ23_RS14655	3006953..3007438	-	486	WP_000214307.1	antirestriction protein	-
HHJ23_RS14660	3007530..3008348	-	819	WP_097726879.1	DUF945 domain-containing protein	-
HHJ23_RS14665	3008448..3008681	-	234	WP_001119717.1	DUF905 family protein	-
HHJ23_RS14670	3008760..3009215	-	456	WP_001504120.1	hypothetical protein	-
HHJ23_RS14675	3009291..3010013	-	723	Protein_2874	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T155203 WP_000854686.1 NZ_CP051738:c3005003-3004620 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T155203 NZ_CP068696:2925652-2925936 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13938.69 Da
• Isoelectric Point: 5.0823

>AT155203 WP_001285602.1 NZ_CP051738:c3005464-3005084 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT155203 NZ_CP068696:2925414-2925662 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA