Detailed information of TA system TA155201

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2656954..2657592
• Replicon: chromosome
• Accession: NZ_CP051738
• Organism: Escherichia coli strain SCU-105

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B7N4J4
• Locus tag: HHJ23_RS12905
• Protein ID: WP_000813797.1
• Coordinates: 2657416..2657592 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HHJ23_RS12900
• Protein ID: WP_076611057.1
• Coordinates: 2656954..2657370 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ23_RS12880	2652106..2653047	-	942	WP_001251335.1	ABC transporter permease	-
HHJ23_RS12885	2653048..2654061	-	1014	WP_000220413.1	ABC transporter ATP-binding protein	-
HHJ23_RS12890	2654079..2655224	-	1146	WP_000047447.1	ABC transporter substrate-binding protein	-
HHJ23_RS12895	2655469..2656875	-	1407	WP_000760613.1	PLP-dependent aminotransferase family protein	-
HHJ23_RS12900	2656954..2657370	-	417	WP_076611057.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
HHJ23_RS12905	2657416..2657592	-	177	WP_000813797.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
HHJ23_RS12910	2657814..2658044	+	231	WP_000494244.1	YncJ family protein	-
HHJ23_RS12915	2658136..2660097	-	1962	WP_001309488.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
HHJ23_RS12920	2660170..2660706	-	537	WP_000429161.1	DNA-binding transcriptional regulator SutR	-
HHJ23_RS12925	2660759..2661970	+	1212	WP_001323162.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6724.76 Da
• Isoelectric Point: 11.5666

>T155201 WP_000813797.1 NZ_CP051738:c2657592-2657416 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T155201 NZ_CP068696:c1467447-1466920 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15251.65 Da
• Isoelectric Point: 4.5908

>AT155201 WP_076611057.1 NZ_CP051738:c2657370-2656954 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT155201 NZ_CP068696:c1467734-1467444 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Toxin

• AlphaFold DB: A0A829J715