Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4177833..4178451 Replicon chromosome
Accession NZ_CP051735
Organism Escherichia coli strain SCU-108

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HHJ26_RS19925 Protein ID WP_001291435.1
Coordinates 4177833..4178051 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HHJ26_RS19930 Protein ID WP_000344800.1
Coordinates 4178077..4178451 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ26_RS19890 4173120..4173692 + 573 WP_000779831.1 YbaY family lipoprotein -
HHJ26_RS19895 4173723..4174034 - 312 WP_000409908.1 MGMT family protein -
HHJ26_RS19905 4174413..4174766 + 354 WP_000878140.1 DUF1428 domain-containing protein -
HHJ26_RS19910 4174808..4176358 - 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HHJ26_RS19915 4176522..4176992 - 471 WP_000136192.1 YlaC family protein -
HHJ26_RS19920 4177108..4177659 - 552 WP_000102543.1 maltose O-acetyltransferase -
HHJ26_RS19925 4177833..4178051 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HHJ26_RS19930 4178077..4178451 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HHJ26_RS19935 4178996..4182145 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HHJ26_RS19940 4182168..4183361 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T155175 WP_001291435.1 NZ_CP051735:c4178051-4177833 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T155175 NZ_CP068689:392383-392730 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT155175 WP_000344800.1 NZ_CP051735:c4178451-4178077 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT155175 NZ_CP068689:392730-393029 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References