Detailed information of TA system TA155168

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3568628..3569462
• Replicon: chromosome
• Accession: NZ_CP051735
• Organism: Escherichia coli strain SCU-108

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A1J6XFW9
• Locus tag: HHJ26_RS17045
• Protein ID: WP_000854770.1
• Coordinates: 3569085..3569462 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HHJ26_RS17040
• Protein ID: WP_001332042.1
• Coordinates: 3568628..3568996 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ26_RS17015	3565752..3565910	+	159	WP_001323397.1	DUF905 family protein	-
HHJ26_RS17020	3566065..3566883	+	819	WP_001234738.1	DUF945 domain-containing protein	-
HHJ26_RS17025	3567225..3567689	+	465	WP_000855061.1	antirestriction protein	-
HHJ26_RS17030	3567705..3568181	+	477	WP_001557203.1	RadC family protein	-
HHJ26_RS17035	3568244..3568465	+	222	WP_000692323.1	DUF987 domain-containing protein	-
HHJ26_RS17040	3568628..3568996	+	369	WP_001332042.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HHJ26_RS17045	3569085..3569462	+	378	WP_000854770.1	TA system toxin CbtA family protein	Toxin
HHJ26_RS17050	3569459..3569947	+	489	WP_000761690.1	hypothetical protein	-
HHJ26_RS17055	3569964..3570140	+	177	WP_000839286.1	DUF957 domain-containing protein	-
HHJ26_RS25635	3570240..3570398	+	159	WP_001467148.1	hypothetical protein	-
HHJ26_RS17070	3570762..3570938	+	177	Protein_3328	helix-turn-helix domain-containing protein	-
HHJ26_RS17075	3571420..3572957	+	1538	WP_085953974.1	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3554444..3579316	24872

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14196.37 Da
• Isoelectric Point: 8.7438

>T155168 WP_000854770.1 NZ_CP051735:3569085-3569462 [Escherichia coli]
MKTLPDTHVRKVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Nucleotide

• Length: 378 bp

>T155168 NZ_CP068686:184820-185131 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13677.38 Da
• Isoelectric Point: 6.5931

>AT155168 WP_001332042.1 NZ_CP051735:3568628-3568996 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAFYPTSETKK

Nucleotide

• Length: 369 bp

>AT155168 NZ_CP068686:185128-185547 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Structures

Toxin

• AlphaFold DB: A0A1J6XFW9