Detailed information of TA system TA155167

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3312214..3313048
• Replicon: chromosome
• Accession: NZ_CP051735
• Organism: Escherichia coli strain SCU-108

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B7MK10
• Locus tag: HHJ26_RS15750
• Protein ID: WP_000854820.1
• Coordinates: 3312214..3312591 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: B7MK11
• Locus tag: HHJ26_RS15755
• Protein ID: WP_001285610.1
• Coordinates: 3312680..3313048 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ26_RS15730	3308778..3310316	-	1539	WP_001187191.1	lysine decarboxylation/transport transcriptional activator CadC	-
HHJ26_RS15735	3311150..3311710	-	561	Protein_3067	DUF4942 domain-containing protein	-
HHJ26_RS15740	3311795..3311992	-	198	WP_085949158.1	DUF957 domain-containing protein	-
HHJ26_RS15745	3312020..3312217	-	198	Protein_3069	hypothetical protein	-
HHJ26_RS15750	3312214..3312591	-	378	WP_000854820.1	type IV toxin-antitoxin system toxin CbtA	Toxin
HHJ26_RS15755	3312680..3313048	-	369	WP_001285610.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HHJ26_RS15760	3313128..3313349	-	222	WP_000692347.1	DUF987 domain-containing protein	-
HHJ26_RS15765	3313436..3313912	-	477	WP_001186193.1	RadC family protein	-
HHJ26_RS15770	3313927..3314406	-	480	WP_000706978.1	antirestriction protein	-
HHJ26_RS15775	3314672..3315490	-	819	WP_001175155.1	DUF945 domain-containing protein	-
HHJ26_RS15780	3315580..3315813	-	234	WP_001278287.1	DUF905 family protein	-
HHJ26_RS15785	3315819..3316496	-	678	WP_016235129.1	hypothetical protein	-
HHJ26_RS15790	3316647..3317327	-	681	WP_001278649.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3311147..3338241	27094

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14043.12 Da
• Isoelectric Point: 7.8839

>T155167 WP_000854820.1 NZ_CP051735:c3312591-3312214 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Nucleotide

• Length: 378 bp

>T155167 NZ_CP068686:139642-140112 [Klebsiella pneumoniae subsp. pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13606.39 Da
• Isoelectric Point: 6.0618

>AT155167 WP_001285610.1 NZ_CP051735:c3313048-3312680 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT155167 NZ_CP068686:139202-139645 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Toxin

• AlphaFold DB: A0A0E2KXX6