Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 816836..817667 Replicon chromosome
Accession NZ_CP051735
Organism Escherichia coli strain SCU-108

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag HHJ26_RS03860 Protein ID WP_000854814.1
Coordinates 817293..817667 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag HHJ26_RS03855 Protein ID WP_001285586.1
Coordinates 816836..817204 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ26_RS03820 812053..813123 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
HHJ26_RS03825 813259..813936 + 678 WP_001362823.1 hypothetical protein -
HHJ26_RS03830 813952..814362 + 411 WP_000846704.1 hypothetical protein -
HHJ26_RS03835 814583..815404 + 822 WP_001234569.1 DUF945 domain-containing protein -
HHJ26_RS03840 815495..815980 + 486 WP_000213703.1 antirestriction protein -
HHJ26_RS03845 815996..816472 + 477 WP_001351157.1 RadC family protein -
HHJ26_RS03850 816541..816762 + 222 WP_000692323.1 DUF987 domain-containing protein -
HHJ26_RS03855 816836..817204 + 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HHJ26_RS03860 817293..817667 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
HHJ26_RS03865 817664..817858 + 195 WP_000988601.1 hypothetical protein -
HHJ26_RS03870 817871..817984 + 114 WP_001161660.1 DUF957 domain-containing protein -
HHJ26_RS03875 818273..818419 - 147 Protein_762 transposase domain-containing protein -
HHJ26_RS03880 818473..818655 + 183 WP_001016348.1 hypothetical protein -
HHJ26_RS03885 818756..819085 - 330 WP_000450409.1 DUF496 family protein -
HHJ26_RS03890 819257..820315 - 1059 WP_001200890.1 FUSC family protein -
HHJ26_RS03895 820513..820986 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
HHJ26_RS03900 821105..822271 - 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T155160 WP_000854814.1 NZ_CP051735:817293-817667 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T155160 NZ_CP068684:c5014438-5014091 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT155160 WP_001285586.1 NZ_CP051735:816836-817204 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT155160 NZ_CP068684:c5014091-5013792 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References