Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2229315..2229953 Replicon chromosome
Accession NZ_CP051733
Organism Escherichia coli strain SCU-109

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HHJ27_RS10600 Protein ID WP_000813794.1
Coordinates 2229315..2229491 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HHJ27_RS10605 Protein ID WP_001270286.1
Coordinates 2229537..2229953 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ27_RS10580 2224937..2226148 - 1212 WP_071600865.1 BenE family transporter YdcO -
HHJ27_RS10585 2226201..2226737 + 537 WP_001595717.1 DNA-binding transcriptional regulator SutR -
HHJ27_RS10590 2226810..2228771 + 1962 WP_001595719.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HHJ27_RS10595 2228863..2229093 - 231 WP_000494241.1 YncJ family protein -
HHJ27_RS10600 2229315..2229491 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HHJ27_RS10605 2229537..2229953 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HHJ27_RS10610 2230032..2231438 + 1407 WP_001595721.1 PLP-dependent aminotransferase family protein -
HHJ27_RS10615 2231683..2232828 + 1146 WP_000047452.1 ABC transporter substrate-binding protein -
HHJ27_RS10620 2232846..2233859 + 1014 WP_001595723.1 ABC transporter ATP-binding protein -
HHJ27_RS10625 2233860..2234801 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T155133 WP_000813794.1 NZ_CP051733:2229315-2229491 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T155133 NZ_CP068680:2021779-2022186 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTAGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT155133 WP_001270286.1 NZ_CP051733:2229537-2229953 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT155133 NZ_CP068680:2021532-2021798 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References