Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1846841..1847625 Replicon chromosome
Accession NZ_CP051733
Organism Escherichia coli strain SCU-109

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag HHJ27_RS08700 Protein ID WP_001595626.1
Coordinates 1846841..1847335 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID L4JCW6
Locus tag HHJ27_RS08705 Protein ID WP_001110447.1
Coordinates 1847332..1847625 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ27_RS08680 1842034..1843131 + 1098 WP_001441925.1 flagellar basal body P-ring protein FlgI -
HHJ27_RS08685 1843131..1844072 + 942 WP_001366226.1 flagellar assembly peptidoglycan hydrolase FlgJ -
HHJ27_RS08690 1844138..1845781 + 1644 WP_000096478.1 flagellar hook-associated protein FlgK -
HHJ27_RS08695 1845793..1846746 + 954 WP_001212768.1 flagellar hook-associated protein FlgL -
HHJ27_RS08700 1846841..1847335 - 495 WP_001595626.1 GNAT family N-acetyltransferase Toxin
HHJ27_RS08705 1847332..1847625 - 294 WP_001110447.1 DUF1778 domain-containing protein Antitoxin
HHJ27_RS08710 1847758..1850943 - 3186 WP_001595627.1 ribonuclease E -
HHJ27_RS08715 1851516..1852475 + 960 WP_000846342.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18065.97 Da        Isoelectric Point: 8.2617

>T155128 WP_001595626.1 NZ_CP051733:c1847335-1846841 [Escherichia coli]
MIQAPEPLIARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

>T155128 NZ_CP068680:1309597-1309704 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11109.69 Da        Isoelectric Point: 10.5423

>AT155128 WP_001110447.1 NZ_CP051733:c1847625-1847332 [Escherichia coli]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp

>AT155128 NZ_CP068680:c1309549-1309483 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L4JCW6

References