Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1590826..1591531 Replicon chromosome
Accession NZ_CP051733
Organism Escherichia coli strain SCU-109

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag HHJ27_RS07495 Protein ID WP_000539521.1
Coordinates 1591145..1591531 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HHJ27_RS07490 Protein ID WP_001280945.1
Coordinates 1590826..1591155 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ27_RS07475 1585983..1586894 + 912 WP_001236042.1 glutathione ABC transporter permease GsiD -
HHJ27_RS07480 1587072..1589420 + 2349 WP_001595546.1 EAL domain-containing protein -
HHJ27_RS07485 1589428..1590756 + 1329 WP_000086872.1 GGDEF domain-containing protein -
HHJ27_RS07490 1590826..1591155 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
HHJ27_RS07495 1591145..1591531 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ27_RS07500 1591757..1593082 - 1326 WP_000049378.1 30S ribosomal protein S12 methylthiotransferase RimO -
HHJ27_RS07505 1593295..1593678 + 384 WP_000497137.1 biofilm formation regulator BssR -
HHJ27_RS07510 1593789..1594904 + 1116 WP_001595547.1 aldose sugar dehydrogenase YliI -
HHJ27_RS07515 1594901..1595527 - 627 WP_001595548.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T155127 WP_000539521.1 NZ_CP051733:c1591531-1591145 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T155127 NZ_CP068680:1309114-1309221 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT155127 WP_001280945.1 NZ_CP051733:c1591155-1590826 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT155127 NZ_CP068680:c1309057-1309000 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References