Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1148116..1148734 Replicon chromosome
Accession NZ_CP051733
Organism Escherichia coli strain SCU-109

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HHJ27_RS05420 Protein ID WP_001291435.1
Coordinates 1148116..1148334 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HHJ27_RS05425 Protein ID WP_000344800.1
Coordinates 1148360..1148734 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ27_RS05385 1143405..1143977 + 573 WP_000779831.1 YbaY family lipoprotein -
HHJ27_RS05390 1144008..1144319 - 312 WP_000409911.1 MGMT family protein -
HHJ27_RS05400 1144698..1145051 + 354 WP_001550741.1 DUF1428 family protein -
HHJ27_RS05405 1145093..1146643 - 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HHJ27_RS05410 1146807..1147277 - 471 WP_000136192.1 YlaC family protein -
HHJ27_RS05415 1147393..1147944 - 552 WP_000102564.1 maltose O-acetyltransferase -
HHJ27_RS05420 1148116..1148334 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HHJ27_RS05425 1148360..1148734 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HHJ27_RS05430 1149280..1152429 - 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
HHJ27_RS05435 1152452..1153645 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T155126 WP_001291435.1 NZ_CP051733:c1148334-1148116 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T155126 NZ_CP068680:1308631-1308738 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT155126 WP_000344800.1 NZ_CP051733:c1148734-1148360 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT155126 NZ_CP068680:c1308573-1308517 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References