Detailed information of TA system TA155121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 524596..525416
• Replicon: chromosome
• Accession: NZ_CP051733
• Organism: Escherichia coli strain SCU-109

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: HHJ27_RS02515
• Protein ID: WP_001054376.1
• Coordinates: 525159..525416 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HHJ27_RS02510
• Protein ID: WP_000215866.1
• Coordinates: 524596..525147 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ27_RS02485	520291..521604	-	1314	WP_000460846.1	galactitol-specific PTS transporter subunit IIC	-
HHJ27_RS02490	521616..521894	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
HHJ27_RS02495	521891..523012	-	1122	WP_000010835.1	M42 family metallopeptidase	-
HHJ27_RS24440	523257..523373	-	117	Protein_476	VOC family protein	-
HHJ27_RS02500	523411..523671	-	261	WP_000084876.1	hypothetical protein	-
HHJ27_RS02505	523798..524544	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
HHJ27_RS02510	524596..525147	-	552	WP_000215866.1	N-acetyltransferase	Antitoxin
HHJ27_RS02515	525159..525416	-	258	WP_001054376.1	hypothetical protein	Toxin
HHJ27_RS02520	525793..526092	-	300	WP_024186563.1	GNAT family N-acetyltransferase	-
HHJ27_RS02525	526170..527396	+	1227	Protein_482	helicase YjhR	-
HHJ27_RS02530	527979..528959	-	981	WP_001765419.1	sialate O-acetylesterase	-
HHJ27_RS02535	529024..530130	-	1107	WP_001044124.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T155121 WP_001054376.1 NZ_CP051733:c525416-525159 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T155121 NZ_CP068680:c66214-65816 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20493.64 Da
• Isoelectric Point: 6.8758

>AT155121 WP_000215866.1 NZ_CP051733:c525147-524596 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKETDLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT155121 NZ_CP068680:c66510-66217 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: S1PA82