Detailed information of TA system TA155103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4063572..4064392
• Replicon: chromosome
• Accession: NZ_CP051727
• Organism: Escherichia coli strain SCU-111

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: HHJ28_RS19375
• Protein ID: WP_001054376.1
• Coordinates: 4063572..4063829 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HHJ28_RS19380
• Protein ID: WP_001519303.1
• Coordinates: 4063841..4064392 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ28_RS19355	4058858..4059964	+	1107	WP_135149994.1	N-acetylneuraminate epimerase	-
HHJ28_RS19360	4060029..4061009	+	981	WP_001519307.1	transposase	-
HHJ28_RS19365	4061592..4062833	-	1242	Protein_3790	helicase YjhR	-
HHJ28_RS19370	4062896..4063195	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
HHJ28_RS19375	4063572..4063829	+	258	WP_001054376.1	hypothetical protein	Toxin
HHJ28_RS19380	4063841..4064392	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
HHJ28_RS19385	4064444..4064605	+	162	WP_001519302.1	hypothetical protein	-
HHJ28_RS19390	4064642..4065190	+	549	WP_001519301.1	hypothetical protein	-
HHJ28_RS19395	4065317..4065577	+	261	WP_000084876.1	hypothetical protein	-
HHJ28_RS24305	4065615..4065731	+	117	Protein_3797	VOC family protein	-
HHJ28_RS19400	4065976..4067097	+	1122	WP_000010833.1	M42 family metallopeptidase	-
HHJ28_RS19405	4067094..4067372	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
HHJ28_RS19410	4067384..4068697	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimC / fimI / fimA / fimE / fimB	4052587..4072612	20025

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T155103 WP_001054376.1 NZ_CP051727:4063572-4063829 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T155103 NZ_CP068641:1585061-1585363 [Vibrio parahaemolyticus]
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTGTCTGACCTCAATGATATCGCTGAATATATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCGGAGTCAGGTCGTATTCCGC
CTGAACTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGCGTTTTTTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGAGTAAGCAGTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT155103 WP_001519303.1 NZ_CP051727:4063841-4064392 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT155103 NZ_CP068641:1584816-1585073 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCATGACACTAAAGAACCAGT
GTTAATTACCGAGCATGGTAAGCCATCTGCGTATCTCGTTGATGTTGATGACTATGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCAAGAGGTGAGCGTGCGCTAGCTGACGGTAAAGTGGTAAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA

Structures

Toxin

• AlphaFold DB: S1PA82