Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3909715..3910265 Replicon chromosome
Accession NZ_CP051727
Organism Escherichia coli strain SCU-111

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag HHJ28_RS18630 Protein ID WP_001160966.1
Coordinates 3909715..3910029 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag HHJ28_RS18635 Protein ID WP_000125566.1
Coordinates 3910032..3910265 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ28_RS18605 3905390..3906676 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
HHJ28_RS18610 3906676..3907665 + 990 WP_000241229.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
HHJ28_RS18615 3907662..3908483 + 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HHJ28_RS18620 3908486..3908863 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
HHJ28_RS18625 3908870..3909718 + 849 WP_001765384.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
HHJ28_RS18630 3909715..3910029 - 315 WP_001160966.1 CcdB family protein Toxin
HHJ28_RS18635 3910032..3910265 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HHJ28_RS18640 3910351..3910830 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
HHJ28_RS18645 3911022..3912884 - 1863 WP_001765385.1 glutathione-regulated potassium-efflux system protein KefC -
HHJ28_RS18650 3912877..3913407 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
HHJ28_RS18655 3913515..3914846 - 1332 WP_001183207.1 MFS transporter -
HHJ28_RS18660 3914905..3915192 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T155099 WP_001160966.1 NZ_CP051727:c3910029-3909715 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T155099 NZ_CP068638:c1928607-1928305 [Vibrio parahaemolyticus]
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGGGTAAGCAATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT155099 WP_000125566.1 NZ_CP051727:c3910265-3910032 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT155099 NZ_CP068638:c1928852-1928595 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACCGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGATGGTAAAGTTGTAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References