Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3718844..3719642 Replicon chromosome
Accession NZ_CP051727
Organism Escherichia coli strain SCU-111

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag HHJ28_RS17750 Protein ID WP_000854730.1
Coordinates 3719265..3719642 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag HHJ28_RS17745 Protein ID WP_001285481.1
Coordinates 3718844..3719218 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ28_RS17705 3714819..3715271 + 453 WP_000682723.1 hypothetical protein -
HHJ28_RS17710 3715389..3715622 + 234 WP_001213776.1 DUF905 family protein -
HHJ28_RS17715 3715722..3716543 + 822 WP_001234359.1 DUF945 domain-containing protein -
HHJ28_RS17720 3716543..3716788 + 246 WP_001164966.1 hypothetical protein -
HHJ28_RS17725 3716882..3717355 + 474 WP_001313575.1 antirestriction protein -
HHJ28_RS17730 3717371..3717847 + 477 WP_001313574.1 RadC family protein -
HHJ28_RS17735 3717910..3718131 + 222 WP_000692315.1 DUF987 domain-containing protein -
HHJ28_RS17740 3718150..3718794 + 645 WP_000086759.1 hypothetical protein -
HHJ28_RS17745 3718844..3719218 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ28_RS17750 3719265..3719642 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
HHJ28_RS17755 3719639..3720131 + 493 Protein_3479 hypothetical protein -
HHJ28_RS17760 3720210..3721198 - 989 Protein_3480 IS630 family transposase -
HHJ28_RS17765 3721346..3722939 - 1594 Protein_3481 IS66 family transposase -
HHJ28_RS17770 3722970..3723320 - 351 WP_000624707.1 IS66 family insertion sequence element accessory protein TnpB -
HHJ28_RS17775 3723317..3723608 - 292 Protein_3483 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T155098 WP_000854730.1 NZ_CP051727:3719265-3719642 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T155098 NZ_CP068638:1834625-1834915 [Vibrio parahaemolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTATCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT155098 WP_001285481.1 NZ_CP051727:3718844-3719218 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT155098 NZ_CP068638:1834387-1834635 [Vibrio parahaemolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCCTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References