Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4303127..4303953 Replicon chromosome
Accession NZ_CP051725
Organism Escherichia coli strain SCU-112

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HHJ29_RS20550 Protein ID WP_094249044.1
Coordinates 4303127..4303501 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HHJ29_RS20555 Protein ID WP_024186744.1
Coordinates 4303591..4303953 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ29_RS20525 4300656..4301729 - 1074 WP_001327207.1 integrase arm-type DNA-binding domain-containing protein -
HHJ29_RS20535 4302193..4302345 - 153 WP_001555250.1 hypothetical protein -
HHJ29_RS20540 4302430..4302627 - 198 WP_000839235.1 DUF957 domain-containing protein -
HHJ29_RS20545 4302639..4303130 - 492 WP_000976831.1 hypothetical protein -
HHJ29_RS20550 4303127..4303501 - 375 WP_094249044.1 TA system toxin CbtA family protein Toxin
HHJ29_RS20555 4303591..4303953 - 363 WP_024186744.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ29_RS20560 4304032..4304253 - 222 WP_000692312.1 DUF987 domain-containing protein -
HHJ29_RS20565 4304322..4304798 - 477 WP_001186708.1 RadC family protein -
HHJ29_RS20570 4304814..4305299 - 486 WP_000206667.1 antirestriction protein -
HHJ29_RS20575 4305391..4306209 - 819 WP_001234592.1 DUF945 domain-containing protein -
HHJ29_RS20580 4306549..4307619 - 1071 WP_000102675.1 patatin-like phospholipase family protein -
HHJ29_RS20585 4307616..4308521 - 906 WP_000203561.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(16-115)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14051.07 Da        Isoelectric Point: 7.8045

>T155069 WP_094249044.1 NZ_CP051725:c4303501-4303127 [Escherichia coli]
MKTLPDTHIREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTQFADERVIELHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T155069 NZ_CP068618:c4794024-4793740 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13354.17 Da        Isoelectric Point: 6.6247

>AT155069 WP_024186744.1 NZ_CP051725:c4303953-4303591 [Escherichia coli]
VSDTLPGTTHPDNNRPWWGLPCTVMPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSGEL
NPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSETKK

Download         Length: 363 bp

>AT155069 NZ_CP068618:c4794256-4794014 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References