Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3922457..3923255 Replicon chromosome
Accession NZ_CP051725
Organism Escherichia coli strain SCU-112

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag HHJ29_RS18700 Protein ID WP_000854730.1
Coordinates 3922878..3923255 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag HHJ29_RS18695 Protein ID WP_001285482.1
Coordinates 3922457..3922831 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ29_RS18655 3918432..3918884 + 453 WP_000682723.1 hypothetical protein -
HHJ29_RS18660 3919002..3919235 + 234 WP_001213776.1 DUF905 family protein -
HHJ29_RS18665 3919335..3920156 + 822 WP_021566768.1 DUF945 domain-containing protein -
HHJ29_RS18670 3920156..3920401 + 246 WP_001164966.1 hypothetical protein -
HHJ29_RS18675 3920495..3920968 + 474 WP_000855076.1 antirestriction protein -
HHJ29_RS18680 3920984..3921460 + 477 WP_001313574.1 RadC family protein -
HHJ29_RS18685 3921523..3921744 + 222 WP_000692315.1 DUF987 domain-containing protein -
HHJ29_RS18690 3921763..3922407 + 645 WP_000086759.1 hypothetical protein -
HHJ29_RS18695 3922457..3922831 + 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ29_RS18700 3922878..3923255 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
HHJ29_RS18705 3923252..3923744 + 493 Protein_3665 hypothetical protein -
HHJ29_RS18710 3923823..3924811 - 989 Protein_3666 IS630 family transposase -
HHJ29_RS18715 3924959..3925147 - 189 Protein_3667 IS66 family transposase -
HHJ29_RS18720 3925208..3925438 + 231 Protein_3668 IS110 family transposase -
HHJ29_RS18725 3926071..3926352 - 282 WP_000133418.1 hypothetical protein -
HHJ29_RS18730 3926426..3926968 - 543 WP_000835284.1 terminase small subunit -
HHJ29_RS18735 3927172..3927585 - 414 WP_000224592.1 hypothetical protein -
HHJ29_RS18740 3927598..3927933 - 336 WP_000380882.1 head decoration protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3920495..3948072 27577


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T155061 WP_000854730.1 NZ_CP051725:3922878-3923255 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T155061 NZ_CP068618:325718-326086 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT155061 WP_001285482.1 NZ_CP051725:3922457-3922831 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT155061 NZ_CP068618:325500-325721 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References