Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3628901..3629519 Replicon chromosome
Accession NZ_CP051725
Organism Escherichia coli strain SCU-112

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HHJ29_RS17360 Protein ID WP_001291435.1
Coordinates 3629301..3629519 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag HHJ29_RS17355 Protein ID WP_001620248.1
Coordinates 3628901..3629275 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ29_RS17345 3623991..3625184 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HHJ29_RS17350 3625207..3628356 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
HHJ29_RS17355 3628901..3629275 + 375 WP_001620248.1 Hha toxicity modulator TomB Antitoxin
HHJ29_RS17360 3629301..3629519 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HHJ29_RS17365 3629692..3630243 + 552 WP_000102539.1 maltose O-acetyltransferase -
HHJ29_RS17370 3630359..3630829 + 471 WP_001304825.1 YlaC family protein -
HHJ29_RS17375 3630993..3632543 + 1551 WP_001528761.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HHJ29_RS17380 3632585..3632938 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HHJ29_RS17390 3633317..3633628 + 312 WP_000409908.1 MGMT family protein -
HHJ29_RS17395 3633659..3634231 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T155060 WP_001291435.1 NZ_CP051725:3629301-3629519 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T155060 NZ_CP068617:c21484-21068 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14556.45 Da        Isoelectric Point: 5.1718

>AT155060 WP_001620248.1 NZ_CP051725:3628901-3629275 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLKESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT155060 NZ_CP068617:c21711-21481 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References